Reactome | SYVN1(1-617) [endoplasmic reticulum membrane]

SYVN1(1-617) [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-535496

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SYVN1, E3 ubiquitin-protein ligase synoviolin, SYVN1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75460

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External Reference Information

External Reference

UniProt:Q86TM6 SYVN1

Gene Names

SYVN1, HRD1, KIAA1810

Chain

chain:1-617

Reference Genes

BioGPS Gene:84447 SYVN1

COSMIC (genes):SYVN1 SYVN1

CTD Gene:84447 SYVN1

dbSNP Gene:84447 SYVN1

ENSEMBL:ENSG00000162298 SYVN1

ENSEMBL_homo_sapiens_GENE:ENSG00000162298.19 SYVN1

HGNC:20738 SYVN1

KEGG Gene (Homo sapiens):84447 SYVN1

Monarch:84447 SYVN1

NCBI Gene:84447 SYVN1

OMIM:608046 SYVN1

UCSC:Q86TM6 SYVN1

Reference Transcript

Other Identifiers

11716172_at

11758745_at

16740342

225090_PM_at

225090_at

3377475

3377476

3377477

3377479

3377480

3377483

3377484

3377486

3377487

3377488

3377489

3377490

3377491

3377493

3377495

3377496

3377497

3377499

3377500

3377502

3377504

3377505

78756_at

7949383

84447

A_23_P138826

A_24_P381224

GE79795

GO:0000836

GO:0000839

GO:0002327

GO:0002376

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005790

GO:0006511

GO:0006886

GO:0012501

GO:0016020

GO:0016567

GO:0016740

GO:0023052

GO:0030154

GO:0030163

GO:0030433

GO:0030970

GO:0036211

GO:0036503

GO:0036513

GO:0043226

GO:0044322

GO:0046872

GO:0048856

GO:0050821

GO:0051082

GO:0051087

GO:0051117

GO:0061630

GO:0070936

GO:0140096

GO:1902236

GO:1990381

HMNXSV003040770

Hs.75859.1.A1_3p_at

ILMN_1803143

ILMN_2339691

PH_hs_0023795

PH_hs_0032654

TC11001929.hg

Participates

as a component of

SYVN1 dimer [endoplasmic reticulum membrane] (Homo sapiens)

as an output of

Expression of SYVN1 (HRD1) (Homo sapiens)

as a member of

ERAD E3 ligases [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

sel-11 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

sip3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Syvn1 [endoplasmic reticulum membrane] (Rattus norvegicus)

SYVN1 [endoplasmic reticulum membrane] (Bos taurus)

SYVN1 [endoplasmic reticulum membrane] (Canis familiaris)

SYVN1 [endoplasmic reticulum membrane] (Sus scrofa)

SYVN1(1-617) [endoplasmic reticulum membrane] (Danio rerio)

SYVN1(1-617) [endoplasmic reticulum membrane] (Dictyostelium discoideum)

SYVN1(1-617) [endoplasmic reticulum membrane] (Mus musculus)

syvn1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Ghost homologue of SYVN1(1-617) [endoplasmic reticulum membrane] (Gallus gallus)

hrd1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_757385.1, XP_011543605.1, NP_115807.1

OpenTargets

ENSG00000162298

GeneCards

Q86TM6

HPA

ENSG00000162298-SYVN1

Ensembl

ENSP00000436984, ENSP00000366395, ENST00000307289, ENST00000377190, ENSP00000294256, ENST00000294256, ENSG00000162298, ENSP00000302035, ENST00000526060

PRO

Q86TM6

Pharos - Targets

Q86TM6

HMDB Protein

HMDBP09317

PDB

6A3Z

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBU6 FA8A1			0.731	20
UniProt:Q9UBV2 SEL1L	1	SEL1L [endoplasmic reticulum membrane] (R-HSA-1911545)	0.708	20
UniProt:Q9Y385 UBE2J1	1	UBE2J1 [cytosol] (R-HSA-947625)	0.702	15
UniProt:Q9Y4E8 USP25	1	USP15 [cytosol] (R-HSA-2173138)	0.668	8
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.61	5
UniProt:Q9Y679 AUP1			0.597	8
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.597	9
UniProt:O94905 ERLIN2	3	ERLIN2 [endoplasmic reticulum membrane] (R-HSA-8866520) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane] (R-HSA-8853122) EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane] (R-HSA-8853148)	0.564	2
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.564	2
UniProt:O75460 ERN1	2	p-S724-ERN1 [endoplasmic reticulum membrane] (R-HSA-381029) ERN1 [endoplasmic reticulum membrane] (R-HSA-381076)	0.524	2
UniProt:O75460-1 ERN1			0.499	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.462	2
UniProt:Q15011 HERPUD1	1	HERPUD1 [endoplasmic reticulum membrane] (R-HSA-535608)	0.462	10

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