Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TPP1 [lysosomal lumen]
Stable Identifier
R-HSA-535504
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
Tripeptidyl-peptidase 1, TPP1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q53EZ4
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of TPP1 (Homo sapiens)
TPP1 [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14773 TPP1
Gene Names
TPP1, CLN2, GIG1, UNQ267/PRO304
Chain
signal peptide:1-19, propeptide:20-195, chain:196-563
Reference Genes
BioGPS Gene:1200 TPP1
COSMIC (genes):TPP1 TPP1
CTD Gene:1200 TPP1
dbSNP Gene:1200 TPP1
ENSEMBL:ENSG00000166340 TPP1
ENSEMBL_homo_sapiens_GENE:ENSG00000166340.18 TPP1
HGNC:2073 TPP1
KEGG Gene (Homo sapiens):1200 TPP1
Monarch:1200 TPP1
NCBI Gene:1200 TPP1
OMIM:607998 TPP1
UCSC:O14773 TPP1
Reference Transcript
RefSeq:NM_000391.3 TPP1
Other Identifiers
11725032_a_at
11748341_a_at
11748342_x_at
11752596_s_at
11752817_s_at
11752885_x_at
11753248_a_at
11753249_x_at
11757469_s_at
1200
16655907
16735137
16735152
18671321
18671322
18671323
18671324
18671325
18671326
18671327
200742_PM_s_at
200742_s_at
200743_PM_s_at
200743_s_at
214196_PM_s_at
214196_s_at
32824_at
3361030
3361031
3361032
3361033
3361034
3361035
3361036
3361037
3361038
3361040
3361042
3361043
3361044
3361045
3361046
3361047
3361048
3361049
3361051
3361054
3361055
3361056
3361058
3361060
3361061
3361063
3361064
3361065
3361067
3361069
3361070
3361071
7892758
7892766
7893029
7894195
7894492
7895866
7946221
7946228
868_at
A_24_P38815
A_33_P3324454
GE54344
GO:0003824
GO:0004175
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0006508
GO:0006629
GO:0007040
GO:0007399
GO:0007417
GO:0008233
GO:0008236
GO:0008240
GO:0008289
GO:0016787
GO:0030154
GO:0030163
GO:0030855
GO:0031410
GO:0035727
GO:0042277
GO:0042470
GO:0043171
GO:0043202
GO:0043226
GO:0045121
GO:0045453
GO:0046872
GO:0048856
GO:0050877
GO:0050885
GO:0055037
GO:0070062
GO:0070198
GO:0120146
GO:0140096
GO:1905146
HMNXSV003005971
Hs.20478.0.A1_3p_a_at
Hs.20478.1.A1_3p_a_at
ILMN_1729234
PH_hs_0025203
TC11001361.hg
TC11001362.hg
TC11003034.hg
U13991_at
g5597012_3p_a_at
Participates
as an output of
Expression of TPP1 (Homo sapiens)
Cross References
RefSeq
NP_000382.3
OpenTargets
ENSG00000166340
HPA
ENSG00000166340-TPP1
GeneCards
O14773
Ensembl
ENST00000642892
,
ENSP00000494165
,
ENSP00000493657
,
ENSP00000299427
,
ENSP00000495893
,
ENST00000299427
,
ENST00000645620
,
ENST00000647152
,
ENST00000533371
,
ENSG00000166340
,
ENSP00000437066
PRO
O14773
Pharos - Targets
O14773
Orphanet
15652
HMDB Protein
HMDBP14587
PDB
3EE6
,
3EDY
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45974-2 USP5
0.556
3
UniProt:Q6P3S6 FBX42
0.556
3
UniProt:Q96D59 RN183
0.556
3
UniProt:Q53EZ4 CEP55
0.556
3
UniProt:Q9NSE2 CISH
1
CISH [cytosol]
(R-HSA-1169213)
0.556
3
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.556
3
UniProt:Q9UKA2 FBXL4
1
FBXL4 [cytosol]
(R-HSA-8850899)
0.556
3
UniProt:Q8NAP3 ZBT38
0.556
3
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:Q9NWX5-2 Q9NWX52
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:E5LBV4 E5LBV4
0.524
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text