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CUL7 [cytosol]
Stable Identifier
R-HSA-535534
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cullin-7, CUL7_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of Cullin-7 (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CUL9:RBX1 ubiquitinates BIRC5 (Homo sapiens)
CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
NEDD8-CUL9:RBX1:CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 (Homo sapiens)
CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
NEDD8-CUL9:RBX1:CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
CUL7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14999 CUL7
Gene Names
CUL7, KIAA0076
Chain
chain:1-1698
Reference Genes
BioGPS Gene:9820 CUL7
COSMIC (genes):CUL7 CUL7
CTD Gene:9820 CUL7
dbSNP Gene:9820 CUL7
ENSEMBL:ENSG00000044090 CUL7
HGNC:21024 CUL7
KEGG:hsa:9820 CUL7
Monarch:9820 CUL7
NCBI Gene:9820 CUL7
OMIM:609577 CUL7
UCSC:Q14999 CUL7
Reference Transcript
RefSeq:NM_001168370.1 CUL7
RefSeq:NM_014780.4 CUL7
Other Identifiers
11721385_a_at
11721386_s_at
11747908_s_at
17019287
203558_3p_at
203558_PM_at
203558_at
241746_PM_at
241746_at
241747_PM_s_at
241747_s_at
243073_PM_at
243073_at
2907777
2907782
2954351
2954353
2954354
2954356
2954357
2954360
2954361
2954362
2954363
2954364
2954365
2954366
2954367
2954368
2954370
2954371
2954372
2954373
2954374
2954377
2954378
2954379
2954380
2954381
2954384
2954385
2954387
2954388
2954389
2954390
2954391
2954392
2954393
2954394
2954395
2954396
2954397
2954398
2954399
2954400
2954401
2954402
2954403
2954408
2954409
2954410
2954411
2954413
2954415
2954416
2954417
2954418
2954421
2954422
2954424
2954425
2954426
36084_PM_at
36084_at
53104_r_at
8126482
8126484
8126486
91553_at
9820
A_23_P19348
D38548_at
GE57192
GE58624
GE862407
GO:0000226
GO:0000281
GO:0000910
GO:0001570
GO:0001837
GO:0001890
GO:0005515
GO:0005680
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006508
GO:0006511
GO:0007010
GO:0007030
GO:0007088
GO:0016567
GO:0030154
GO:0031461
GO:0031467
GO:0031625
GO:0043226
GO:0048471
GO:0048856
GO:0050775
GO:1990393
HMNXSV003031196
Hs.157710.0.A1_3p_at
Hs.250843.0.A1_3p_at
ILMN_1672393
PH_hs_0025126
TC06001742.hg
g7661893_3p_at
g7661893_3p_s_at
g7661893_3p_x_at
Participates
as a component of
CUL7:CCDC8:OBSL1 [cytosol] (Homo sapiens)
RBX1:CUL7:SKP1:FBXW8:GLMN [cytosol] (Homo sapiens)
as an output of
Expression of Cullin-7 (Homo sapiens)
Inferred To
Cul7 [cytosol]
(Mus musculus)
Cul7 [cytosol]
(Rattus norvegicus)
cul9 [cytosol]
(Xenopus tropicalis)
CUL7 [cytosol]
(Bos taurus)
CUL7 [cytosol]
(Canis familiaris)
CUL7 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_055595.2
,
NP_001161842.1
ENSEMBL
ENSP00000265348
,
ENST00000690231
,
ENSP00000508461
,
ENST00000265348
OpenTargets
ENSG00000044090
HPA
ENSG00000044090-CUL7
PRO
Q14999
Pharos - Targets
Q14999
GlyGen
Q14999
Orphanet
CUL7
PDB
7Z8B
,
2JNG
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.919
18
UniProt:O75147-2 OBSL1
0.544
4
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.527
4
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.527
2
UniProt:Q96BR6 ZNF669
1
ZNF669 [nucleoplasm]
(R-HSA-2248869)
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:O14978 ZNF263
1
ZNF263 [nucleoplasm]
(R-HSA-1027393)
0.527
2
UniProt:P04004 VTN
1
VTN [extracellular region]
(R-HSA-215971)
0.527
2
UniProt:P63208 SKP1
2
SKP1 [cytosol]
(R-HSA-174150)
SKP1 [nucleoplasm]
(R-HSA-187538)
0.527
4
UniProt:O14958 CASQ2
1
CASQ2 [sarcoplasmic reticulum membrane]
(R-HSA-2855225)
0.527
2
UniProt:Q12798 CETN1
7
PolyUb-Misfolded CETN1 [late endosome lumen]
(R-HSA-9659982)
CETN1 [cilium]
(R-HSA-9639700)
Misfolded CETN1 [cilium]
(R-HSA-9639714)
Misfolded CETN1 [cytosol]
(R-HSA-9640113)
Ub-Misfolded CETN1 [cytosol]
(R-HSA-9641110)
PolyUb-Misfolded CETN1 [cytosol]
(R-HSA-9641126)
PolyUb-Misfolded CETN1 [lysosomal lumen]
(R-HSA-9659990)
0.527
2
UniProt:Q9NXS3 KLH28
0.527
2
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