Reactome: A Curated Pathway Database

PAK1-3 autophosphorylates

Stable Identifier
R-HSA-5357472
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Increased PAK1-3 catalytic activity is associated with autophosphorylation of key residues, including one site in the regulatory portion (S144 in PAK1) and another in the so-called activation loop (T423 in PAK1).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of PAK1,2,3 dimer [cytosol] PAK1,2,3 dimer [cytosol] protein serine/threonine kinase activity (0004674)
Orthologous Events