PAK1-3 phosphorylates VE-cadherin

Stable Identifier
R-HSA-5357477
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated PAK then phosphorylates a serene residue (S665) within a conserved motif in the cytoplasmic tail of VE-cadherin. VE-cadherin is also phosphorylated by c-Src in a manner dependent on TSAD (Sun et al. 2012, Lambeng et al. 2005). Serine-phosphorylated VE-cadherin recruits beta-arrestin 2 which promotes the internalization of VE-cadherin into clathrin-coated pits. This process leads to the disassembly of endothelial-cell junctions, resulting in the enhanced permeability of the blood-vessel wall (Gavard & Gutkind 2006).

Literature References
PubMed ID Title Journal Year
17060906 VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

Gavard, J, Gutkind, JS

Nat. Cell Biol. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S,T-PAK1,2,3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created