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MSH2 [nucleoplasm]
Stable Identifier
R-HSA-5357525
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA mismatch repair protein Msh2, MSH2_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8IY92 SLX4
Expand all
DNA Repair (Homo sapiens)
Mismatch Repair (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (Homo sapiens)
Formation of MSH2:MSH3 Complex (Homo sapiens)
MSH2 [nucleoplasm] (Homo sapiens)
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (Homo sapiens)
Formation of MSH2:MSH6 Complex (Homo sapiens)
MSH2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of DNA repair (Homo sapiens)
Diseases of Mismatch Repair (MMR) (Homo sapiens)
Defective Mismatch Repair Associated With MSH3 (Homo sapiens)
MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
MSH2 [nucleoplasm] (Homo sapiens)
Defective Mismatch Repair Associated With MSH6 (Homo sapiens)
MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
MSH2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of DNA Repair Genes (Homo sapiens)
TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)
MSH2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43246 MSH2
Gene Names
MSH2
Chain
initiator methionine:, chain:2-934
Reference Genes
BioGPS Gene:4436 MSH2
COSMIC (genes):MSH2 MSH2
CTD Gene:4436 MSH2
dbSNP Gene:4436 MSH2
ENSEMBL:ENSG00000095002 MSH2
ENSEMBL_homo_sapiens_GENE:ENSG00000095002.15 MSH2
HGNC:7325 MSH2
KEGG Gene (Homo sapiens):4436 MSH2
Monarch:4436 MSH2
NCBI Gene:4436 MSH2
OMIM:609309 MSH2
UCSC:P43246 MSH2
Reference Transcript
RefSeq:NM_000251.2 MSH2
RefSeq:NM_001258281.1 MSH2
Other Identifiers
11719416_s_at
11744721_s_at
11749490_x_at
16879883
209421_PM_at
209421_at
2480993
2480994
2480995
2480996
2480997
2480998
2480999
2481000
2481002
2481003
2481007
2481010
2481016
2481017
2481018
2481020
2481022
2481023
2481025
2481029
2481030
2481031
4436
8041867
860_at
861_g_at
A_14_P118153
A_14_P118983
A_23_P102471
A_33_P3287502
GE58211
GO:0000166
GO:0000278
GO:0000287
GO:0000400
GO:0000781
GO:0001701
GO:0002204
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003690
GO:0003697
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0006091
GO:0006119
GO:0006281
GO:0006298
GO:0006301
GO:0006302
GO:0006310
GO:0006312
GO:0006974
GO:0007281
GO:0008094
GO:0008340
GO:0008584
GO:0008630
GO:0010165
GO:0010224
GO:0012501
GO:0016020
GO:0016446
GO:0016447
GO:0016787
GO:0016887
GO:0019237
GO:0019724
GO:0022414
GO:0023052
GO:0030154
GO:0030183
GO:0030983
GO:0031573
GO:0032137
GO:0032139
GO:0032142
GO:0032143
GO:0032181
GO:0032301
GO:0032302
GO:0032357
GO:0032405
GO:0042771
GO:0042803
GO:0043226
GO:0043524
GO:0043531
GO:0043570
GO:0045190
GO:0045910
GO:0048298
GO:0048304
GO:0048856
GO:0051096
GO:0051726
GO:0071168
GO:0140097
GO:0140299
GO:0140657
GO:0140664
HMNXSV003037227
HMNXSV003050617
ILMN_1737413
ILMN_2203453
PH_hs_0025783
TC02000295.hg
TC02003219.hg
U03911_at
g432997_3p_at
g432997_3p_x_at
Participates
as an input of
MSH6 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
MSH3 variant:MSH2-defective DNA mismatch repair (Homo sapiens)
Formation of MSH2:MSH3 Complex (Homo sapiens)
Formation of MSH2:MSH6 Complex (Homo sapiens)
as a component of
MSH2:MSH3:ADP [nucleoplasm] (Homo sapiens)
MSH2:MSH3:ATP [nucleoplasm] (Homo sapiens)
MSH2:MSH6:ATP [nucleoplasm] (Homo sapiens)
MSH2:MSH6:ADP [nucleoplasm] (Homo sapiens)
as an output of
TP53 and AP-1 stimulate MSH2 expression (Homo sapiens)
Other forms of this molecule
MSH2 R406* [nucleoplasm]
MSH2 GLN601TER [nucleoplasm]
Inferred To
msh-2 [nucleoplasm]
(Caenorhabditis elegans)
MSH2 [nucleoplasm]
(Bos taurus)
MSH2 [nucleoplasm]
(Canis familiaris)
MSH2 [nucleoplasm]
(Dictyostelium discoideum)
MSH2 [nucleoplasm]
(Drosophila melanogaster)
MSH2 [nucleoplasm]
(Gallus gallus)
MSH2 [nucleoplasm]
(Mus musculus)
MSH2 [nucleoplasm]
(Plasmodium falciparum)
MSH2 [nucleoplasm]
(Rattus norvegicus)
MSH2 [nucleoplasm]
(Saccharomyces cerevisiae)
MSH2 [nucleoplasm]
(Schizosaccharomyces pombe)
MSH2 [nucleoplasm]
(Sus scrofa)
msh2 [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001245210.1
,
NP_000242.1
OpenTargets
ENSG00000095002
GeneCards
P43246
HPA
ENSG00000095002-MSH2
Ensembl
ENSG00000095002
,
ENSP00000233146
,
ENST00000543555
,
ENSP00000442697
,
ENST00000233146
PRO
P43246
Pharos - Targets
P43246
Orphanet
16466
PDB
3THW
,
2O8C
,
8AG6
,
8OM9
,
2O8B
,
2O8F
,
3THZ
,
2O8E
,
8OLX
,
8OM5
,
8OMO
,
2O8D
,
3THY
,
8OMQ
,
3THX
,
8OMA
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20585 MSH3
2
MSH3 K383Rfs*32 [nucleoplasm]
(R-HSA-5578664)
MSH3 [nucleoplasm]
(R-HSA-5357519)
0.918
14
UniProt:P52701 MSH6
2
MSH6 L222* [nucleoplasm]
(R-HSA-5632954)
MSH6 [nucleoplasm]
(R-HSA-5357528)
0.91
11
UniProt:Q9NXL9 MCM9
0.69
9
UniProt:Q9UQ84-1 EXO1
0.573
3
UniProt:Q8IY92 SLX4
1
SLX4 [nucleoplasm]
(R-HSA-5686477)
0.567
5
UniProt:Q92624 APBP2
0.556
3
UniProt:Q9UJA3 MCM8
1
MCM8 [nucleoplasm]
(R-HSA-3006646)
0.527
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q9H4L7 SMRCD
0.527
5
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.527
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:O60729 CDC14B
1
CDC14B [nucleoplasm]
(R-HSA-3214897)
0.519
2
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.508
2
UniProt:P39875
1
EXO1 [nucleoplasm]
(R-SCE-5357514)
0.508
2
IntAct:EBI-1187714 41
0.499
2
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
0.499
2
UniProt:O00716 E2F3
2
p-E2F3 [nucleoplasm]
(R-HSA-187933)
E2F3 [nucleoplasm]
(R-HSA-68655)
0.483
2
UniProt:Q9Q2G4 Q9Q2G4
0.462
2
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