Caspase activation via extrinsic apoptotic signalling pathway

Stable Identifier
R-HSA-5357769
Type
Pathway
Species
Homo sapiens
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Summation

Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the activation of Caspase-3, though the two pathways communicate through the pro-apoptotic Bcl-2 family member Bid before uniting at the shared activation of Caspase-3.

Literature References
PubMed ID Title Journal Year
11048727 The biochemistry of apoptosis. Nature 2000
Participants
Participant Of
hasEvent
Event Information
Orthologous Events