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BIRC2,3,4 [cytosol]
Stable Identifier
R-HSA-5357900
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
RIPK3 binds RIPK1 (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
CLIP3 and CYLD bind TNF signaling complex (Homo sapiens)
CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
K63polyUb-RIPK1 is deubiquitinated (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
LUBAC ubiquitinates RIPK1 at K627 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
OPTN recruits CYLD to the TNFR1 complex (Homo sapiens)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4:TAX1BP1:TNFAIP3 [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains (Homo sapiens)
K48polyUb-RIPK1-containing TNFR1 complexes [plasma membrane] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
RIPK1-containg TNFR1 signaling complexes [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNFR1-induced NF-kappa-B signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
TNFR1-induced proapoptotic signaling (Homo sapiens)
TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
BIRC2,3,4 [cytosol] (Homo sapiens)
Participants
members
BIRC2 [cytosol]
(Homo sapiens)
BIRC3 [cytosol]
(Homo sapiens)
candidates
XIAP [cytosol]
(Homo sapiens)
Participates
as an output of
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Homo sapiens)
as a component of
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Homo sapiens)
TNF-α:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane] (Homo sapiens)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Homo sapiens)
as an input of
TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) (Homo sapiens)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
This entity regulates
Negatively
RIPK3 binds RIPK1
(Homo sapiens)
Inferred To
BIRC2,3,4 [cytosol]
(Bos taurus)
BIRC2,3,4 [cytosol]
(Canis familiaris)
BIRC2,3,4 [cytosol]
(Danio rerio)
BIRC2,3,4 [cytosol]
(Drosophila melanogaster)
BIRC2,3,4 [cytosol]
(Gallus gallus)
BIRC2,3,4 [cytosol]
(Mus musculus)
BIRC2,3,4 [cytosol]
(Rattus norvegicus)
BIRC2,3,4 [cytosol]
(Schizosaccharomyces pombe)
BIRC2,3,4 [cytosol]
(Sus scrofa)
BIRC2,3,4 [cytosol]
(Xenopus tropicalis)
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