MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

Stable Identifier
R-HSA-5358512
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is activated by interaction with MSH2:MSH3 (MutSbeta) (Zhang et al. 2005, and inferred from activation of MLH1:PMS2 by MSH2:MSH6). MLH1:PMS2 makes a nick in the strand of DNA that will be repaired (Kadyrov et al. 2006).

Literature References
PubMed ID Title Journal Year
16873062 Endonucleolytic function of MutLalpha in human mismatch repair

Kadyrov, FA, Dzantiev, L, Constantin, N, Modrich, P

Cell 2006
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM

Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endonuclease activity of MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed