Reactome: A Curated Pathway Database

MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more

Stable Identifier
R-HSA-5358512
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The latent endonuclease activity of MLH1:PMS2 (MutLalpha) is activated by interaction with MSH2:MSH3 (MutSbeta) (Zhang et al. 2005, and inferred from activation of MLH1:PMS2 by MSH2:MSH6). MLH1:PMS2 makes a nick in the strand of DNA that will be repaired (Kadyrov et al. 2006).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
endonuclease activity of MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] MLH1:PMS2:MSH2:MSH3:ATP:PCNA:DNA containing IDL of 2 bases or more [nucleoplasm] endonuclease activity (0004519)
Inferred From