DNA polymerase delta polymerizes DNA across single stranded gap

Stable Identifier
R-HSA-5358579
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

DNA polymerase delta synthesizes DNA across a single-stranded gap during mismatch repair (Longley et al. 1997, Zhang et al. 2005, Constantin et al. 2005, reviewed in Prindle and Loeb 2012). RPA stimulates the activity of DNA polymerase delta (Dong et al. 1999). DNA polymerase delta does not displace strands during synthesis (Randahl et al. 1988).

Literature References
PubMed ID Title Journal Year
9882630 In vitro analysis of the zinc-finger motif in human replication protein A

Dong, J, Park, JS, Lee, SH

Biochem. J. 1999
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM

Cell 2005
9099749 DNA polymerase delta is required for human mismatch repair in vitro

Longley, MJ, Pierce, AJ, Modrich, P

J. Biol. Chem. 1997
23065663 DNA polymerase delta in DNA replication and genome maintenance

Prindle, MJ, Loeb, LA

Environ. Mol. Mutagen. 2012
2842325 DNA-repair reactions by purified HeLa DNA polymerases and exonucleases

Randahl, H, Elliott, GC, Linn, S

J. Biol. Chem. 1988
16188885 Human mismatch repair: reconstitution of a nick-directed bidirectional reaction

Constantin, N, Dzantiev, L, Kadyrov, FA, Modrich, P

J. Biol. Chem. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA-directed DNA polymerase activity of DNA Polymerase delta tetramer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed