S45 mutants of beta-catenin aren't phosphorylated

Stable Identifier
R-HSA-5358751
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Summation

S45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish the CK1alpha phosphorylation site of beta-catenin which acts as a critical priming site for GSK3 phosphorylation of T41( and subsequently S37 and S33) thus preventing its ubiquitin-mediated degradation (Morin et al, 1997; Amit et al, 2002).

Literature References
PubMed ID Title Journal Year
9065402 Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

Morin, PJ, Sparks, AB, Korinek, V, Barker, N, Clevers, HC, Vogelstein, B, Kinzler, KW

Science 1997
12000790 Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

Amit, S, Hatzubai, A, Birman, Y, Andersen, JS, Ben-Shushan, E, Mann, M, Ben-Neriah, Y, Alkalay, I

Genes Dev 2002
10921899 Wnt signaling and cancer

Polakis, P

Genes Dev. 2000
Participants
Events
Participant Of
hasEvent
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database
Authored
Rothfels, K  (2014-04-02)
Reviewed
Salahshor, S  (2014-05-12)
Woodgett, J  (2014-05-22)