S45 mutants of beta-catenin aren't phosphorylated

Stable Identifier
R-HSA-5358751
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

S45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish the CK1alpha phosphorylation site of beta-catenin which acts as a critical priming site for GSK3 phosphorylation of T41( and subsequently S37 and S33) thus preventing its ubiquitin-mediated degradation (Morin et al, 1997; Amit et al, 2002).

Participants
Participant Of
Authored
Reviewed
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
BioModels Database