Reactome: A Curated Pathway Database

MSH2:MSH3 exchanges ADP for ATP

Stable Identifier
R-HSA-5358919
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).

Literature References
Participants
Participant Of
Inferred From