MSH2:MSH3 exchanges ADP for ATP

Stable Identifier
R-HSA-5358919
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

After binding a mismatch, the MSH2:MSH3 (MutSbeta) heterodimer exchanges ADP for ATP, which changes the conformation of MSH2:MSH3 to a sliding clamp or molecular switch able to diffuse in one direction along duplex DNA (Gu et al. 1998, Zhang et al. 2005, and inferred from MSH2:MSH6).

Literature References
PubMed ID Title Journal Year
9469823 ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

Gu, L, Hong, Y, McCulloch, S, Watanabe, H, Li, GM

Nucleic Acids Res. 1998
16143102 Reconstitution of 5'-directed human mismatch repair in a purified system

Zhang, Y, Yuan, F, Presnell, SR, Tian, K, Gao, Y, Tomkinson, AE, Gu, L, Li, GM

Cell 2005
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