Glycosylation of Hh

Stable Identifier
R-HSA-5362386
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Proteomic studies show that the C-termini of SHH and IHH are N-glycosylated (Liu et al, 2005). A N278A mutant of SHH does not undergo cholesterol-mediated autoproteolysis suggesting that glycosylation is a prerequisite for this processing step (Huang et al, 2013).

Literature References
PubMed ID Title Journal Year
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu, T, Qian, WJ, Gritsenko, MA, Camp, DG, Monroe, ME, Moore, RJ, Smith, RD

J. Proteome Res. 2005
23867461 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum

Huang, CH, Hsiao, HT, Chu, YR, Ye, Y, Chen, X

J. Biol. Chem. 2013
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