Hh C-terminal fragments are degraded by the proteasome

Stable Identifier
R-HSA-5362448
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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After retrotranslocation to the cytosol, Hh-C is degraded by the proteasome (Chen et al, 2011; Huang et al, 2013).

Literature References
PubMed ID Title Journal Year
23867461 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum

Huang, CH, Hsiao, HT, Chu, YR, Ye, Y, Chen, X

J. Biol. Chem. 2013
21357747 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Chen, X, Tukachinsky, H, Huang, CH, Jao, C, Chu, YR, Tang, HY, Mueller, B, Schulman, S, Rapoport, TA, Salic, A

J. Cell Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created