ALDHs oxidise atRAL to atRA

Stable Identifier
R-HSA-5362522
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ALDHs oxidise atRAL to atRA
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Several aldehyde dehydrogenases catalyse the irreversible oxidation of retinal to retinoic acid. ALDH1A1, 2 and 3 utilise NAD+ as cofactor to oxidise all-trans-retinal (atRAL) to all-trans-retinoic acid (atRA). They are cytosolic enzymes which are functional in their homotetrameric states (Yoshida et al. 1993, Duester 2008, Bchini et al. 2013).
Literature References
Participants
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Output
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as an event of
Catalyst Activity

retinal dehydrogenase (NAD+) activity of ALDH1A1,2,3 tetramers [cytosol]

Physical Entity
ALDH1A1,2,3 tetramers [cytosol] (Homo sapiens)
Activity
retinal dehydrogenase (NAD+) activity (GO:0001758)
Orthologous Events
ALDHs oxidise atRAL to atRA (Bos taurus)
ALDHs oxidise atRAL to atRA (Caenorhabditis elegans)
ALDHs oxidise atRAL to atRA (Canis familiaris)
ALDHs oxidise atRAL to atRA (Danio rerio)
ALDHs oxidise atRAL to atRA (Dictyostelium discoideum)
ALDHs oxidise atRAL to atRA (Drosophila melanogaster)
ALDHs oxidise atRAL to atRA (Gallus gallus)
ALDHs oxidise atRAL to atRA (Mus musculus)
ALDHs oxidise atRAL to atRA (Rattus norvegicus)
ALDHs oxidise atRAL to atRA (Saccharomyces cerevisiae)
ALDHs oxidise atRAL to atRA (Schizosaccharomyces pombe)
ALDHs oxidise atRAL to atRA (Sus scrofa)
ALDHs oxidise atRAL to atRA (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2014-04-16)
Reviewed
Duester, G  (2014-07-28)
Napoli, JL  (2014-09-01)
Created
Jassal, B  (2014-04-16)
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