RA biosynthesis pathway

Stable Identifier
R-HSA-5365859
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde dehydrogenase (RALDH) gene families (Das et al. 2014, Napoli 2012).

Literature References
PubMed ID Title Journal Year
24393720 Retinoic acid signaling pathways in development and diseases

Das, BC, Thapa, P, Karki, R, Das, S, Mahapatra, S, Liu, TC, Torregroza, I, Wallace, DP, Kambhampati, S, Van Veldhuizen, P, Verma, A, Ray, SK, Evans, T

Bioorg. Med. Chem. 2014
21621639 Physiological insights into all-trans-retinoic acid biosynthesis

Napoli, JL

Biochim. Biophys. Acta 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created