DPH7 hydrolyzes a methyl group on Me-diphthine EEF2

Stable Identifier
R-HSA-5367022
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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By analogy to the activity of its experimentally characterized budding yeast homolog (Lin et al. 2014; Schaffrath et al. 2014), cytosolic DPH7 is inferred to catalyze the removal of a methyl group of Me-diphthine EEF2, yielding diphthine EEF2.

Literature References
PubMed ID Title Journal Year
24739148 Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis

Lin, Z, Su, X, Chen, W, Ci, B, Zhang, S, Lin, H

J. Am. Chem. Soc. 2014
25352115 The Diphthamide Modification Pathway from Saccharomyces cerevisiae - Revisited

Schaffrath, R, Abdel-Fattah Mohamed, W, Klassen, R, Stark, MJ

Mol. Microbiol. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein methylesterase activity of DPH7 [cytosol]
Physical Entity
Activity
Inferred From
Authored
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Created