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GADD45GIP1 [mitochondrial matrix]
Stable Identifier
R-HSA-5368253
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Growth arrest and DNA damage-inducible proteins-interacting protein 1, G45IP_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
GADD45GIP1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TAE8 GADD45GIP1
Gene Names
GADD45GIP1, MRPL59, PLINP1, PRG6
Chain
chain:1-222
Reference Genes
BioGPS Gene:90480 GADD45GIP1
COSMIC (genes):GADD45GIP1 GADD45GIP1
CTD Gene:90480 GADD45GIP1
dbSNP Gene:90480 GADD45GIP1
ENSEMBL:ENSG00000179271 GADD45GIP1
HGNC:29996 GADD45GIP1
KEGG Gene (Homo sapiens):90480 GADD45GIP1
Monarch:90480 GADD45GIP1
NCBI Gene:90480 GADD45GIP1
OMIM:605162 GADD45GIP1
UCSC:Q8TAE8 GADD45GIP1
Reference Transcript
RefSeq:NM_052850.3 GADD45GIP1
Other Identifiers
0004200332
11719082_a_at
16869387
212891_s_at
3851912
3851913
3851914
3851915
3851916
3851917
3851918
3851919
3851920
8034605
90480
A_23_P39019
A_33_P3273148
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005759
GO:0005840
GO:0006412
GO:0007049
GO:0008150
GO:0009058
GO:0016032
GO:0034641
GO:0043226
GO:0044403
GO:0070125
GO:0070126
GO:0071850
Hs.83135.1.A1_3p_a_at
ILMN_1751530
PH_hs_0027173
TC19001216.hg
Participant Of
hasComponent
39S ribosomal subunit [mitochondrial inner membrane]
Inferred To
CRIF [mitochondrial matrix] (Drosophila melanogaster)
Ghost homologue of GADD45GIP1 [mitochondrial matrix] (Gallus gallus)
GADD45GIP1 [mitochondrial matrix] (Caenorhabditis elegans)
GADD45GIP1 [mitochondrial matrix] (Canis familiaris)
GADD45GIP1 [mitochondrial matrix] (Sus scrofa)
Gadd45gip1 [mitochondrial matrix] (Mus musculus)
Gadd45gip1 [mitochondrial matrix] (Rattus norvegicus)
gadd45gip1-prov [mitochondrial matrix] (Xenopus tropicalis)
gadd45gip1 [mitochondrial matrix] (Danio rerio)
Cross References
RefSeq
NP_443082.2
OpenTargets
ENSG00000179271
GeneCards
Q8TAE8
HPA
ENSG00000179271-GADD45GIP1
Ensembl
ENST00000316939
,
ENSG00000179271
,
ENSP00000323065
PRO
Q8TAE8
PDB
3J9M
,
6I9R
,
3J7Y
,
6NU2
,
5OOL
,
6NU3
,
5OOM
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.635
4
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.593
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:P42227 Stat3
11
Stat3 [cytosol]
(R-MMU-539044)
phospho-Stat3 [nucleoplasm]
(R-MMU-1112554)
phospho-Stat3 [cytosol]
(R-MMU-914048)
p-Y705-Stat3 [cytosol]
(R-MMU-914034)
p(Y705)-Stat3 [nucleoplasm]
(R-MMU-2730582)
Stat3 [cytosol]
(R-MMU-914084)
phospho-Stat3 [cytosol]
(R-MMU-539048)
phospho-Stat3 [cytosol]
(R-MMU-8983130)
phospho-Stat3 [nucleoplasm]
(R-MMU-9027589)
phospho-Stat3 [cytosol]
(R-MMU-8982823)
phospho-Stat3 [nucleoplasm]
(R-MMU-8983188)
0.463
3
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