Reactome | GADD45GIP1 [mitochondrial matrix]

GADD45GIP1 [mitochondrial matrix]

Stable Identifier

R-HSA-5368253

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Growth arrest and DNA damage-inducible proteins-interacting protein 1, G45IP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TAE8 GADD45GIP1

Gene Names

GADD45GIP1, MRPL59, PLINP1, PRG6

Chain

chain:1-222

Reference Genes

BioGPS Gene:90480 GADD45GIP1

COSMIC (genes):GADD45GIP1 GADD45GIP1

CTD Gene:90480 GADD45GIP1

dbSNP Gene:90480 GADD45GIP1

ENSEMBL:ENSG00000179271 GADD45GIP1

HGNC:29996 GADD45GIP1

KEGG Gene (Homo sapiens):90480 GADD45GIP1

Monarch:90480 GADD45GIP1

NCBI Gene:90480 GADD45GIP1

OMIM:605162 GADD45GIP1

UCSC:Q8TAE8 GADD45GIP1

Reference Transcript

RefSeq:NM_052850.3 GADD45GIP1

Other Identifiers

0004200332

11719082_a_at

16869387

212891_s_at

3851912

3851913

3851914

3851915

3851916

3851917

3851918

3851919

3851920

3J7Y

3J9M

55205

5OOL

5OOM

65048

6NU2

6NU3

8034605

90480

A_23_P39019

A_33_P3273148

AAH04944

AAH13027

AAH13039

AAH69200

AAL85877

AAM10639

AF147080

AF475095

AF479749

AJ295986

AJ429498

BC004944

BC013027

BC013039

BC069200

CAC82499

CAD22344

CCDS12290

ENSG00000179271

ENSP00000323065

ENST00000316939

ENST00000316939.2

EntrezGene:90480

EntrezGene:GADD45GIP1

GADD45GIP1

GADD45GIP1-201

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005840

GO:0006412

GO:0007049

GO:0008150

GO:0009058

GO:0016032

GO:0032991

GO:0034641

GO:0043226

GO:0044403

GO:0070125

GO:0070126

GO:0071850

HGNC:29996

HPA055205

HPA065048

Hs.83135.1.A1_3p_a_at

ILMN_1751530

IPR018472

MIM:605162

NM_052850

NP_443082

PF10147

PH_hs_0027173

TC19001216.hg

UPI000006E725

Participant Of

hasComponent

39S ribosomal subunit [mitochondrial inner membrane]

Inferred To

Ghost homologue of GADD45GIP1 [mitochondrial matrix] (Gallus gallus)

GADD45GIP1 [mitochondrial matrix] (Bos taurus)

GADD45GIP1 [mitochondrial matrix] (Caenorhabditis elegans)

GADD45GIP1 [mitochondrial matrix] (Canis familiaris)

GADD45GIP1 [mitochondrial matrix] (Danio rerio)

GADD45GIP1 [mitochondrial matrix] (Drosophila melanogaster)

GADD45GIP1 [mitochondrial matrix] (Mus musculus)

GADD45GIP1 [mitochondrial matrix] (Rattus norvegicus)

GADD45GIP1 [mitochondrial matrix] (Sus scrofa)

GADD45GIP1 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_443082.2

OpenTargets

ENSG00000179271

GeneCards

Q8TAE8

PRO

Q8TAE8

PDB

6NU3, 5OOL, 6NU2, 3J9M, 3J7Y, 5OOM

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-914048) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) STAT3 [cytosol] (R-HSA-539044)	0.635	4
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.593	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.488	2
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.488	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.488	2
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.488	2
UniProt:P42227 Stat3	11	phospho-p-STAT3 [cytosol] (R-MMU-8982823) phospho-p-STAT3 [nucleoplasm] (R-MMU-8983188) phospho-p-Y705-STAT3 [nucleoplasm] (R-MMU-9027589) phospho-p-Y705-STAT3 [cytosol] (R-MMU-8983130) phospho-p-Y705,S727-STAT3 [cytosol] (R-MMU-539048) Stat3 [cytosol] (R-MMU-914084) p(Y705)-Stat3 [nucleoplasm] (R-MMU-2730582) p-Y705-Stat3 [cytosol] (R-MMU-914034) phospho-p-Y705-STAT3 [cytosol] (R-MMU-914048) STAT3 [cytosol] (R-MMU-539044) phospho-p-Y705-STAT3 [nucleoplasm] (R-MMU-1112554)	0.463	3