CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression

Stable Identifier
R-HSA-5368580
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

CHD8 is a ATP-dependent chromatin remodeling factor that binds directly to beta-catenin to repress transcription of WNT target genes (Thompson et al, 2008; Sakamoto et al, 2000). ChIP studies show that CHD8 is recruited to the promoters of several beta-catenin-responsive targets, and knockdown of CHD8 results in induction of these target genes in vivo (Thompson et al, 2008). An N-terminal fragment of CHD was independently identified as the rat protein Duplin. Duplin was shown to negatively regulate WNT target gene expression by competing with TCF7L2 for beta-catenin binding (Sakamoto et al, 2000; Kobayashi et al, 2002). A corresponding fragment of CHD8 has not been identified in human cells and its significance is not clear.

Literature References
PubMed ID Title Journal Year
10921920 A novel beta-catenin-binding protein inhibits beta-catenin-dependent Tcf activation and axis formation

Sakamoto, I, Kishida, S, Fukui, A, Kishida, M, Yamamoto, H, Hino, S, Michiue, T, Takada, S, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
18378692 CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes

Thompson, BA, Tremblay, V, Lin, G, Bochar, DA

Mol. Cell. Biol. 2008
10944533 Inhibition of Wnt signaling pathway by a novel axin-binding protein

Kadoya, T, Kishida, S, Fukui, A, Hinoi, T, Michiue, T, Asashima, M, Kikuchi, A

J. Biol. Chem. 2000
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