Reactome | DVL binds CCDC88C

DVL binds CCDC88C

Stable Identifier

R-HSA-5368588

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CCDC88C was identified as Dapple in a screen of mouse brain cDNAs for DVL1-interacting proteins (Oshita et al, 2003). CCDC88C binds to the PDZ domain of DVL through the three amino acids Gly-Cys-Val at the C-terminus, and this interaction negatively regulates canonical WNT signaling (Oshita et al, 2003; Ekici et al, 2010). Interaction between DVL and CCDC88C also regulates signaling in the non-canonical WNT pathway, where the interaction is required for aPKC-mediated RAC activation, lamellipodia formation and cell migration (Ishida-Takagisha et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
14750955	Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway Kikuchi, A, Asashima, M, Michiue, T, Kishida, S, Asahara, T, Oshita, A, Kobayashi, H	Genes Cells	2003
21031079	Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticulum Ekici, AB, Morris-Rosendahl, DJ, Wenzel, D, Boltshauser, E, Lorenz, I, Thiel, CT, Jatzwauk, M, Staatz, G, Sticht, H, Hilfinger, D, Hehr, U, Reis, A, Goecke, TW, Rauch, A	Mol Syndromol	2010
22643886	The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility Murakumo, Y, Kikuchi, A, Weng, L, Asai, N, Asai, M, Watanabe, T, Ushida, K, Enomoto, A, Kato, T, Kaibuchi, K, Matsumoto, S, Ishida-Takagishi, M, Takahashi, M, Hashimoto, T	Nat Commun	2012