Negative regulation of TCF-dependent signaling by DVL-interacting proteins

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R-HSA-5368598
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Pathway
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Homo sapiens
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DVL is a central component of WNT signaling that plays roles in both canonical and non-canonical pathways (reviewed in Gao and Chen, 2010). In the canonical pathway, DVL recruits AXIN from the destruction complex upon WNT stimulation, allowing cytosolic beta-catenin to accumulate (reviewed in MacDonald et al, 2009). DVL activity is regulated by phosphorylation as well as by regulated proteasomal or lysosomal degradation (reviewed in Gao and Chen, 2010). In addition, DVL activity can be regulated by interaction with other proteins; both CXXC4 and CCDC88C were identified as negative regulators of WNT signaling that interact directly with DVL, although the role of these proteins in limiting WNT signaling remain to be fully worked out (Hino et al, 2001; Oshita et al, 2003; Ekici et al, 2010; Ishida-Takagishi et al, 2012).

Literature References
PubMed ID Title Journal Year
20006983 Dishevelled: The hub of Wnt signaling

Gao, C, Chen, YG

Cell. Signal. 2010
11113207 Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein

Hino, S, Kishida, S, Michiue, T, Fukui, A, Sakamoto, I, Takada, S, Asashima, M, Kikuchi, A

Mol. Cell. Biol. 2001
14750955 Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway

Oshita, A, Kishida, S, Kobayashi, H, Michiue, T, Asahara, T, Asashima, M, Kikuchi, A

Genes Cells 2003
21031079 Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticulum

Ekici, AB, Hilfinger, D, Jatzwauk, M, Thiel, CT, Wenzel, D, Lorenz, I, Boltshauser, E, Goecke, TW, Staatz, G, Morris-Rosendahl, DJ, Sticht, H, Hehr, U, Reis, A, Rauch, A

Mol Syndromol 2010
22643886 The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility

Ishida-Takagishi, M, Enomoto, A, Asai, N, Ushida, K, Watanabe, T, Hashimoto, T, Kato, T, Weng, L, Matsumoto, S, Asai, M, Murakumo, Y, Kaibuchi, K, Kikuchi, A, Takahashi, M

Nat Commun 2012
19619488 Wnt/beta-catenin signaling: components, mechanisms, and diseases

MacDonald, BT, Tamai, K, He, X

Dev Cell 2009
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