39S subunit binds 28S subunit:mRNA:fMet-tRNA

Stable Identifier
R-HSA-5389839
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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As inferred from bovine homologs, the 39S ribosomal subunit binds the 28S subunit:mRNA:N-formylmethionyl-tRNA complex, MTIF2 hydrolyzes GTP, then MTIF2, GDP, and MTIF3 dissociate. (MTIF2 has a very low affinity for GDP so it is unclear whether MTIF2 and GDP remain associated after hydrolysis of GTP.) The 28S subunit, 39S subunit, and 55S holoribosome associate with the inner mitochondrial membrane during translation and in the absence of translation.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of 28S ribosomal subunit:MTIF3:MTIF2:GTP:mRNA:fMet-tRNA [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created