TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome

Stable Identifier
R-HSA-5389842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
ReviewStatus
5/5
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TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
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As inferred from bovine homologs, interaction of the cognate aminoacyl-tRNA in the A-site with the codon in the mRNA causes TUFM (EF-Tu) to hydrolyze GTP. TUFM:GDP then dissociates from the ribosome.
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Catalyst Activity

GTPase activity of 55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane]

Physical Entity
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Inferred From
TUFM:GDP dissociates from 55S ribosome (Bos taurus)
Authored
May, B  (2014-04-26)
Reviewed
Chrzanowska-Lightowlers, ZM  (2014-08-29)
Spremulli, LL  (2014-09-20)
Created
May, B  (2014-04-30)
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