28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA

Stable Identifier
R-HSA-5389849
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As inferred from bovine homologs, the 28S ribosomal subunit in a complex with MTIF3 (IF-3Mt, IF3mt) binds mRNA and, at some point, MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP). If an initiation codon is present at the 5' end of the mRNA then MTIF2:GTP assists the binding of N-formylmethionyl-tRNA and a stable, productive initiation complex results. If no initiation codon is present, the mRNA slides through the 28S subunit and then dissociates.

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