Reactome | STAT3 [cytosol]

STAT3 [cytosol]

Stable Identifier

R-HSA-539044

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducer and activator of transcription 3, STAT3_HUMAN

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External Reference Information

External Reference

UniProt:P40763 STAT3

Gene Names

STAT3, APRF

Chain

initiator methionine:, chain:2-770

Reference Genes

COSMIC (genes):STAT3 STAT3

dbSNP Gene:6774 STAT3

ENSEMBL:ENSG00000168610 STAT3

Participates

as a component of

as an input of

as an output of

Expression of STAT3 (Homo sapiens)

as a member of

Other forms of this molecule

p-Y705-STAT3 [nucleoplasm]

p-Y705-STAT3 [cytosol]

p-Y705,S727-STAT3 [cytosol]

p-S727-STAT3 [cytosol]

p-Y705-STAT3 [nucleoplasm]

p-Y705,S727-STAT3 [nucleoplasm]

AcK685- p-Y705,S727-STAT3 [nucleoplasm]

p-STAT3 [cytosol]

p-STAT3 [nucleoplasm]

Unfolded STAT3 [cytosol]

Inferred To

dstD [cytosol] (Dictyostelium discoideum)

dstC [cytosol] (Dictyostelium discoideum)

Homologues of STAT3 [cytosol] (Caenorhabditis elegans)

Homologues of STAT3 [cytosol] (Dictyostelium discoideum)

Homologues of STAT3 [cytosol] (Sus scrofa)

sta-2 [cytosol] (Caenorhabditis elegans)

stat3 [cytosol] (Xenopus tropicalis)

dstB [cytosol] (Dictyostelium discoideum)

Stat3 [cytosol] (Mus musculus)

Stat3 [cytosol] (Rattus norvegicus)

STAT3 [cytosol] (Bos taurus)

STAT3 [cytosol] (Caenorhabditis elegans)

STAT3 [cytosol] (Canis familiaris)

STAT3 [cytosol] (Dictyostelium discoideum)

STAT3 [cytosol] (Gallus gallus)

STAT3 [cytosol] (Sus scrofa)

Stat92E [cytosol] (Drosophila melanogaster)

dstA [cytosol] (Dictyostelium discoideum)

sta-1 [cytosol] (Caenorhabditis elegans)

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.919	15
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.908	10
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.873	10
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.842	8
UniProt:P51813 BMX	3	BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875) BMX(1-242) [cytosol] (R-HSA-351899)	0.83	8
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.83	9
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.775	9
IntAct:EBI-1550784 CDKN1A			0.725	6
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.649	4
UniProt:P30626 SRI	1	SRI [sarcoplasmic reticulum membrane] (R-HSA-5490313)	0.635	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.635	4
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.625	5
UniProt:P06401 PGR	3	monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (R-HSA-4341032) PGR [cytosol] (R-HSA-8948964) PGR [nucleoplasm] (R-HSA-3008952)	0.623	3
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.623	2
UniProt:P45984-1 MAPK9			0.602	3
UniProt:Q810M5 ZDH19			0.576	4
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.564	2
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.558	4
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.556	4
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q9DUM3 Q9DUM3			0.556	4
UniProt:P12268 IMPDH2	4	IMPDH2 [secretory granule lumen] (R-HSA-6803323) IMPDH2 [extracellular region] (R-HSA-6806455) IMPDH2 [ficolin-1-rich granule lumen] (R-HSA-6803330) IMPDH2 [cytosol] (R-HSA-57350)	0.556	3
IntAct:EBI-10178797 4005			0.556	3
UniProt:Q96HA1-2 POM121			0.556	3
UniProt:Q9BXM7 PINK1	5	PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628) PINK1 [cytosol] (R-HSA-5205637) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051)	0.547	2
UniProt:Q8N6P7 IL22RA1	2	IL22RA1 [plasma membrane] (R-HSA-448489) p-Y-251,p-Y301-IL22RA1 [plasma membrane] (R-HSA-8987198)	0.547	2
IntAct:EBI-9914958 STAT3			0.527	3
IntAct:EBI-1265559 MYC			0.527	3
UniProt:Q14289 PTK2B	3	PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721) p-Y-PTK2B [cytosol] (R-HSA-508515)	0.527	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.527	5
UniProt:O75116 ROCK2	2	ROCK2 [cytosol] (R-HSA-419058) Activated ROCK2 [cytosol] (R-HSA-4687775)	0.524	3
UniProt:Q14938-4 NFIX			0.524	3
UniProt:Q14938-3 NFIX			0.524	3
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.512	3
UniProt:Q98PK8 Q98PK8			0.512	3
UniProt:Q9BVP2 GNL3	1	GNL3 [nucleoplasm] (R-HSA-8869324)	0.508	2
UniProt:Q9ULD0 OGDHL			0.508	2
UniProt:Q13011 ECH1	3	ECH1 [mitochondrial matrix] (R-HSA-9838037) ECH1(1-328) [peroxisomal matrix] (R-HSA-9033140) ECH1(1-328) [cytosol] (R-HSA-9033152)	0.508	2
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [plasma membrane] (R-HSA-3828038)	0.508	2
UniProt:P30084 ECHS1	17	ECHS1 [mitochondrial matrix] (R-HSA-54125) A2V ECHS1 [mitochondrial matrix] (R-HSA-9916688) T180A ECHS1 [mitochondrial matrix] (R-HSA-9916687) A238V ECHS1 [mitochondrial matrix] (R-HSA-9916686) A132T ECHS1 [mitochondrial matrix] (R-HSA-9916665) G195S ECHS1 [mitochondrial matrix] (R-HSA-9916681) K273E ECHS1 [mitochondrial matrix] (R-HSA-9916680) R54H ECHS1 [mitochondrial matrix] (R-HSA-9916676) I66T ECHS1 [mitochondrial matrix] (R-HSA-9916659) D150G ECHS1 [mitochondrial matrix] (R-HSA-9916674) A158D ECHS1 [mitochondrial matrix] (R-HSA-9916689) C225R ECHS1 [mitochondrial matrix] (R-HSA-9916672) N59S ECHS1 [mitochondrial matrix] (R-HSA-9916684) A138V ECHS1 [mitochondrial matrix] (R-HSA-9916683) E77Q ECHS1 [mitochondrial matrix] (R-HSA-9916667) F33S ECHS1 [mitochondrial matrix] (R-HSA-9916682) Q159R ECHS1 [mitochondrial matrix] (R-HSA-9916666)	0.508	3
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.508	2
UniProt:P31146 CORO1A	1	CORO1A [cytosol] (R-HSA-9636432)	0.508	2
UniProt:Q96G01 BICD1	1	BICD1 [cytosol] (R-HSA-8848104)	0.508	2
UniProt:Q8TE76 MORC4			0.508	2
UniProt:O14874 BCKDK	5	BCKDK [mitochondrial matrix] (R-HSA-5693129) R224P BCKDK [mitochondrial matrix] (R-HSA-9912466) R174Gfs1* BCKDK [mitochondrial matrix] (R-HSA-9912469) L389P BCKDK [mitochondrial matrix] (R-HSA-9912461) R156* BCKDK [mitochondrial matrix] (R-HSA-9912465)	0.508	2
UniProt:Q06520 SULT2A1	1	SULT2A1 [cytosol] (R-HSA-176559)	0.508	2
UniProt:P22736 NR4A1	2	p-S351-NR4A1 [nucleoplasm] (R-HSA-199846) NR4A1 [nucleoplasm] (R-HSA-199831)	0.508	3
UniProt:P46781 RPS9	2	RPS9 [cytosol] (R-HSA-72387) RPS9 [nucleoplasm] (R-HSA-6790663)	0.508	2
IntAct:EBI-9825772 C-FOS PROMOTER REGION			0.499	2
IntAct:EBI-10039972 MMP2			0.499	2
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.499	7
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.499	4
IntAct:EBI-1108795 NPM			0.499	2
IntAct:EBI-9980755 MIR-155			0.499	2
IntAct:EBI-10952519 STAT			0.499	4
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.499	5
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.488	2
UniProt:Q5VWN6 TASO2			0.488	2
IntAct:EBI-10696506 MPZL1			0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q8NEC7 GSTCD			0.488	2
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.488	2
UniProt:P35219 CAH8			0.488	2
UniProt:Q9Y4J8-9 DTNA			0.488	2
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [cytosol] (R-HSA-187743) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:Q9Y3P9 RABGAP1	1	RABGAP1 [cytosol] (R-HSA-8854144)	0.488	2
UniProt:Q9NVE4 CCD87			0.488	2
UniProt:Q96DZ7 T4S19			0.488	2
UniProt:Q8IZQ1 WDFY3			0.488	2
UniProt:Q6P1L5 F117B			0.488	2
UniProt:Q86WK9 PAQR7			0.488	2
UniProt:Q14847 LASP1			0.488	2
UniProt:Q03181-2 PPARD			0.488	2
UniProt:Q3KNS6 ZN829			0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q9UBX0 HESX1			0.488	2
UniProt:Q6ZVU3 Q6ZVU3			0.488	2
UniProt:Q9Y2X9 ZN281			0.488	2
UniProt:Q15672 TWIST1	1	TWIST1 [nucleoplasm] (R-HSA-445442)	0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:P07949 RET	2	RET [plasma membrane] (R-HSA-8853797) p-5Y-RET [plasma membrane] (R-HSA-8854162)	0.483	3
UniProt:O95661 DIRA3			0.463	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.463	4
UniProt:P35232 PHB	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.463	2
UniProt:Q9UBE8 NLK	3	NLK [cytosol] (R-HSA-4411330) p-T298-NLK [cytosol] (R-HSA-4411398) p-T298-NLK [nucleoplasm] (R-HSA-4411376)	0.462	2
UniProt:Q99062 CSF3R	5	CSF3R [plasma membrane] (R-HSA-6787734) p-4Y-CSF3R [plasma membrane] (R-HSA-9674543) p-4Y-CSF3R [endocytic vesicle membrane] (R-HSA-9705736) K48polyUb-K655,p-4Y-CSF3R [endocytic vesicle membrane] (R-HSA-9705727) K48polyUb-K655,p-4Y-CSF3R [lysosomal membrane] (R-HSA-9707928)	0.462	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.462	3

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