Reactome | RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL

RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL

Stable Identifier

R-HSA-5419165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL

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Multiple reductases may contribute to the reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL), including RDH11 (aka PSDR1, RalR1), RDH14, DHRS3 (aka retSDR1, RDH17) and DHRS4 (aka RRD, SCAD-SRL) (Haeseleer et al. 1998, Haeseleer et al. 2002, Kedishvili et al. 2002, Lin et al. 2001, Zhen et al. 2003, Belyaeva et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
12680773	Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate Lei, Z, Chen, W, Zhang, M, Napoli, JL	Biochemistry	2003
12226107	Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina Haeseleer, F, Jang, GF, Imanishi, Y, Driessen, CA, Matsumura, M, Nelson, PS, Palczewski, K	J. Biol. Chem.	2002
9705317	Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal Haeseleer, F, Huang, J, Lebioda, L, Saari, JC, Palczewski, K	J. Biol. Chem.	1998
18039331	Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity Belyaeva, OV, Korkina, OV, Stetsenko, AV, Kedishvili, NY	FEBS J.	2008
11245473	Prostate short-chain dehydrogenase reductase 1 (PSDR1): a new member of the short-chain steroid dehydrogenase/reductase family highly expressed in normal and neoplastic prostate epithelium Lin, B, White, JT, Ferguson, C, Wang, S, Vessella, R, Bumgarner, R, True, LD, Hood, L, Nelson, PS	Cancer Res.	2001
12036956	Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1) Kedishvili, NY, Chumakova, OV, Chetyrkin, SV, Belyaeva, OV, Lapshina, EA, Lin, DW, Matsumura, M, Nelson, PS	J. Biol. Chem.	2002