55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP

Stable Identifier
R-HSA-5419271
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Binding of the MTRF1L (MTRF1a) termination factor triggers hydrolysis of the peptidyl-tRNA bond by the 39S subunit of the ribosome and release of the translated polypeptide (Soleimanpour-Lichaei et al. 2007, Nozaki et al. 2008, reviewed in Christian and Spremulli 2012). MTRF1L hydrolyzes GTP during the reaction. Stalled ribosomes are rescued by binding of an ICT1 protein in addition to the ICT1 subunit integrated in the 39S subunit (Richter et al. 2010, Akabane et al. 2014).

Literature References
PubMed ID Title Journal Year
25233460 Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria

Akabane, S, Ueda, T, Nierhaus, KH, Takeuchi, N

PLoS Genet. 2014
20186120 A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome

Richter, R, Rorbach, J, Pajak, A, Smith, PM, Wessels, HJ, Huynen, MA, Smeitink, JA, Lightowlers, RN, Chrzanowska-Lightowlers, ZM

EMBO J. 2010
18429816 HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG

Nozaki, Y, Matsunaga, N, Ishizawa, T, Ueda, T, Takeuchi, N

Genes Cells 2008
22172991 Mechanism of protein biosynthesis in mammalian mitochondria

Christian, BE, Spremulli, LL

Biochim. Biophys. Acta 2012
17803939 mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG

Soleimanpour-Lichaei, HR, Kühl, I, Gaisne, M, Passos, JF, Wydro, M, Rorbach, J, Temperley, R, Bonnefoy, N, Tate, W, Lightowlers, R, Chrzanowska-Lightowlers, ZM

Mol. Cell 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created