Mitochondrial translation termination

Stable Identifier
R-HSA-5419276
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Pathway
Species
Homo sapiens
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Translation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al. 2010, Chrzanowska-Lightowlers et al. 2011. Christian and Spremulli 2012). GTP is hydrolyzed, and the aminoacyl bond between the translated polypeptide and the final tRNA at the P site is hydrolyzed by the 39S ribosomal subunit, releasing the translated polypeptide. MRRF (RRF) and GFM2:GTP (EF-G2mt:GTP) then act to release the remaining tRNA and mRNA from the ribosome and dissociate the 55S ribosome into 28S and 39S subunits.

Literature References
PubMed ID Title Journal Year
21873426 Termination of protein synthesis in mammalian mitochondria

Chrzanowska-Lightowlers, ZM, Pajak, A, Lightowlers, RN

J. Biol. Chem. 2011
21118119 Translation termination in human mitochondrial ribosomes

Richter, R, Pajak, A, Dennerlein, S, Rozanska, A, Lightowlers, RN, Chrzanowska-Lightowlers, ZM

Biochem. Soc. Trans. 2010
22172991 Mechanism of protein biosynthesis in mammalian mitochondria

Christian, BE, Spremulli, LL

Biochim. Biophys. Acta 2012
17803939 mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG

Soleimanpour-Lichaei, HR, Kühl, I, Gaisne, M, Passos, JF, Wydro, M, Rorbach, J, Temperley, R, Bonnefoy, N, Tate, W, Lightowlers, R, Chrzanowska-Lightowlers, ZM

Mol. Cell 2007
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