MRRF binds 55S ribosome:mRNA:tRNA

Stable Identifier
R-HSA-5419281
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The mitochondrial ribosome releasing factor MRRF (RRF) binds the 55S ribosome at the A-site after translation has been terminated by MTRF1L (MTRF1a) at a stop codon and the translated polypeptide has been hydrolyzed from the last tRNA, which remains in the P-site (Rorbach et al. 2008).

Literature References
PubMed ID Title Journal Year
18782833 The human mitochondrial ribosome recycling factor is essential for cell viability

Rorbach, J, Richter, R, Wessels, HJ, Wydro, M, Pekalski, M, Farhoud, M, Kühl, I, Gaisne, M, Bonnefoy, N, Smeitink, JA, Lightowlers, RN, Chrzanowska-Lightowlers, ZM

Nucleic Acids Res. 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created