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ZNRD1 [nucleoplasm]
Stable Identifier
R-HSA-5419292
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA-directed RNA polymerase I subunit RPA12, RPA12_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
Transcription of intergenic spacer of the rRNA gene (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
B-WICH complex positively regulates rRNA expression (Homo sapiens)
B-WICH complex binds rDNA promoter (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
B-WICH recruits histone acetyltransferases (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Promoter Escape (Homo sapiens)
Elongation of pre-rRNA transcript (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
Binding of RRN3 to RNA Polymerase I (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Termination (Homo sapiens)
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
ZNRD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P1U0 POLR1H
Gene Names
POLR1H, RPA12, ZNRD1
Chain
chain:1-126
Reference Genes
BioGPS Gene:30834 POLR1H
COSMIC (genes):ZNRD1 POLR1H
CTD Gene:30834 POLR1H
dbSNP Gene:30834 POLR1H
ENSEMBL:ENSG00000066379 ZNRD1
HGNC:13182 POLR1H
Monarch:30834 POLR1H
NCBI Gene:30834 POLR1H
OMIM:607525 POLR1H
UCSC:Q9P1U0 POLR1H
Reference Transcript
RefSeq:NM_014596.5 POLR1H
RefSeq:NM_001278786.1 POLR1H
RefSeq:NM_001278785.1 POLR1H
RefSeq:NM_170783.3 POLR1H
Other Identifiers
11717867_a_at
17006171
17026125
17027364
17030207
17032904
17035064
17037693
17040409
223639_PM_s_at
223639_s_at
227673_3p_at
227673_PM_at
227673_at
228009_PM_x_at
228009_x_at
234114_PM_at
234114_at
234115_PM_s_at
234115_s_at
234530_PM_s_at
234530_s_at
2901334
2901335
2901336
2901337
2901338
2901339
2901340
2901341
2901342
2901343
2901344
2901345
2901347
2901348
2901349
30834
43442_s_at
64458_at
8117822
8179055
A_14_P105584
A_24_P46577
GE54188
GE80296
GO:0000428
GO:0001054
GO:0003676
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005736
GO:0006139
GO:0006351
GO:0006363
GO:0008270
GO:0016740
GO:0043226
GO:0046872
GO:0140098
HMNXSV003047936
Hs.302037.0.A1_3p_at
Hs.57813.1.A1_3p_a_at
Hs.57813.1.A1_3p_at
Hs.57813.1.A1_3p_x_at
ILMN_1692486
ILMN_1722894
ILMN_2398587
PH_hs_0003708
TC06000330.hg
TC6_apd_hap1000021.hg
TC6_cox_hap2000029.hg
TC6_dbb_hap3000022.hg
TC6_mann_hap4000024.hg
TC6_mcf_hap5000018.hg
TC6_qbl_hap6000022.hg
TC6_ssto_hap7000022.hg
g12275846_3p_a_at
Participates
as an input of
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
as a component of
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
Inferred To
ZNRD1 [nucleoplasm]
(Bos taurus)
ZNRD1 [nucleoplasm]
(Caenorhabditis elegans)
ZNRD1 [nucleoplasm]
(Drosophila melanogaster)
ZNRD1 [nucleoplasm]
(Mus musculus)
ZNRD1 [nucleoplasm]
(Plasmodium falciparum)
ZNRD1 [nucleoplasm]
(Rattus norvegicus)
ZNRD1 [nucleoplasm]
(Saccharomyces cerevisiae)
ZNRD1 [nucleoplasm]
(Schizosaccharomyces pombe)
POLR1H [nucleoplasm]
(Canis familiaris)
rpa12 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of ZNRD1 [nucleoplasm]
(Gallus gallus)
Ghost homologue of ZNRD1 [nucleoplasm]
(Sus scrofa)
Ghost homologue of ZNRD1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000066379
ENSEMBL
ENSP00000414720
,
ENSP00000412369
,
ENSP00000399966
,
ENSP00000352333
,
ENST00000437507
,
ENSP00000394779
,
ENST00000420100
,
ENSP00000405264
,
ENST00000453694
,
ENST00000433264
,
ENST00000442585
,
ENST00000437373
,
ENST00000428913
,
ENST00000444027
,
ENST00000451875
,
ENSP00000365978
,
ENSP00000383501
,
ENST00000443494
,
ENST00000432904
,
ENST00000400660
,
ENST00000431416
,
ENSP00000391809
,
ENST00000376782
,
ENSP00000410530
,
ENSP00000414110
,
ENSP00000397636
,
ENSP00000396922
,
ENST00000441251
,
ENSP00000387914
,
ENSP00000413265
,
ENSP00000373108
,
ENSP00000416599
,
ENSP00000410954
,
ENST00000383613
,
ENSP00000395065
,
ENST00000376785
,
ENST00000400659
,
ENSP00000399302
,
ENSP00000410127
,
ENST00000417738
,
ENST00000443142
,
ENSP00000405636
,
ENSP00000407715
,
ENST00000417275
,
ENST00000446493
,
ENSP00000365981
,
ENSP00000331111
,
ENSP00000402198
,
ENSP00000407364
,
ENST00000429558
,
ENST00000412396
,
ENSP00000383500
,
ENST00000400662
,
ENSP00000383503
,
ENST00000332435
,
ENST00000432227
,
ENST00000432545
,
ENSP00000393236
,
ENST00000444794
,
ENST00000431032
,
ENST00000359374
,
ENST00000455948
,
ENSP00000396661
,
ENSP00000395397
HPA
ENSG00000066379-POLR1H
PRO
Q9P1U0
Pharos - Targets
Q9P1U0
GlyGen
Q9P1U0
HMDB Protein
HMDBP11909
PDB
7VBB
,
7OB9
,
7VBA
,
7VBC
,
8A43
,
7OBB
,
7OBA
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54253 ATX1
0.556
3
UniProt:Q8N7C3 TRIMM
0.556
3
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.527
2
UniProt:P61218 POLR2F
2
POLR2F [cytosol]
(R-HSA-1964441)
POLR2F [nucleoplasm]
(R-HSA-83714)
0.527
2
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.527
2
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