SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

Stable Identifier
R-HSA-5423038
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SETD8 methylates lysine-21 of histone H4
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Monomethylation of lysine-21 of histone H4 (H4K20) is performed by SETD8 (KMT5A) (Yin et al. 2005). Trimethylation, performed by SUV420H1 and SUV420H2 and possibly SMYD3 (Foreman et al. 2011), is associated with heterochromatin formation and gene repression (Schotta et al. 2004).

Literature References
PubMed ID Title Journal Year
15964846 SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20

Yin, Y, Liu, C, Tsai, SN, Zhou, B, Ngai, SM, Zhu, G

J. Biol. Chem. 2005
21779408 Structural and functional profiling of the human histone methyltransferase SMYD3

Foreman, KW, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P

PLoS ONE 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone-lysine N-methyltransferase activity of SETD8 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created