Reactome | PHF8 [nucleoplasm]

PHF8 [nucleoplasm]

Stable Identifier

R-HSA-5423096

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone lysine demethylase PHF8, PHF8_HUMAN, JHDM1E

Locations in the PathwayBrowser for interactor UniProt:Q06330 RBPJ

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External Reference Information

External Reference

UniProt:Q9UPP1 PHF8

Gene Names

PHF8, KIAA1111, ZNF422

Chain

chain:1-1060

Reference Genes

BioGPS Gene:23133 PHF8

COSMIC (genes):PHF8 PHF8

CTD Gene:23133 PHF8

dbSNP Gene:23133 PHF8

ENSEMBL:ENSG00000172943 PHF8

HGNC:20672 PHF8

KEGG:hsa:23133 PHF8

Monarch:23133 PHF8

NCBI Gene:23133 PHF8

OMIM:300560 PHF8

UCSC:Q9UPP1 PHF8

Reference Transcript

Participates

as a member of

KDM3A,KDM3B,KDM7A,PHF2:ARID5B,PHF8 [nucleoplasm] (Homo sapiens)

Inferred To

Phf8 [nucleoplasm] (Rattus norvegicus)

PHF8-1 [nucleoplasm] (Caenorhabditis elegans)

PHF8-1 [nucleoplasm] (Danio rerio)

PHF8-1 [nucleoplasm] (Schizosaccharomyces pombe)

PHF8 [nucleoplasm] (Bos taurus)

PHF8 [nucleoplasm] (Canis familiaris)

PHF8 [nucleoplasm] (Mus musculus)

PHF8 [nucleoplasm] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2698

OpenTargets

ENSG00000172943

ENSEMBL

ENSP00000338868, ENSP00000350676, ENST00000357988, ENST00000322659, ENSG00000172943, ENST00000338154, ENSP00000319473

ZINC - Substances

PHF8_HUMAN

ZINC - Biogenic

PHF8_HUMAN

ZINC target

Q9UPP1

PRO

Q9UPP1

GlyGen

Q9UPP1

PDB

3K3O, 7CMZ, 2WWU, 3K3N, 4DO0, 3KV4

ZINC - Metabolites

PHF8_HUMAN

HPA

ENSG00000172943-PHF8

GeneCards

PHF8

Pharos - Targets

Q9UPP1

Orphanet

PHF8

ZINC - Predictions - Purchasable

PHF8_HUMAN

HMDB Protein

HMDBP11880

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y462 ZNF711	1	ZNF711 [nucleoplasm] (R-HSA-2454159)	0.69	7
UniProt:Q01433 AMPD2	1	AMPD2 [cytosol] (R-HSA-49927)	0.527	3
UniProt:Q15013 MD2BP			0.527	3
UniProt:Q16778 H2BC21	9	HIST2H2BE [nucleoplasm] (R-HSA-181908) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) HIST2H2BE [extracellular region] (R-HSA-977571) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539)	0.527	2
UniProt:Q5SXM2 SNAPC4	1	SNAPC4 [nucleoplasm] (R-HSA-83729)	0.527	3
UniProt:Q96QS3 ARX			0.524	3
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.499	2
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	7

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