PHF8 demethylates MeK21-histone H4

Stable Identifier
R-HSA-5423117
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PHF8 (JHDM1E) catalyses demethylation of mono-methylated lysine-21 of histone H4 (H4K20Me1) (Qi et al. 2010, Liu et al. 2010).

Literature References
PubMed ID Title Journal Year
20622854 PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

Liu, W, Tanasa, B, Tyurina, OV, Zhou, TY, Gassmann, R, Liu, WT, Ohgi, KA, Benner, C, Garcia-Bassets, I, Aggarwal, AK, Desai, A, Dorrestein, PC, Glass, CK, Rosenfeld, MG

Nature 2010
20622853 Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development

Qi, HH, Sarkissian, M, Hu, GQ, Wang, Z, Bhattacharjee, A, Gordon, DB, Gonzales, M, Lan, F, Ongusaha, PP, Huarte, M, Yaghi, NK, Lim, H, Garcia, BA, Brizuela, L, Zhao, K, Roberts, TM, Shi, Y

Nature 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
histone demethylase activity of PHF8 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created