AKR dimers reduce AFBDHO to AFBDOH

Stable Identifier
R-HSA-5423637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here).

Literature References
PubMed ID Title Journal Year
9576847 Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase

Ireland, LS, Neal, GE, Harrison, DJ, Hayes, JD

Biochem. J. 1998
16970545 Aldo-keto reductases and bioactivation/detoxication

Penning, TM, Jin, Y

Annu. Rev. Pharmacol. Toxicol. 2007
18416522 Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3

Sutter, CH, Groopman, JD, Jones, LK, Roebuck, BD, Bodreddigari, S, Guengerich, FP, Egner, PA, Kensler, TW, Sutter, TR

Chem. Res. Toxicol. 2008
11409944 Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases

Cai, H, McMahon, M, Guengerich, FP, Deng, Z, Groopman, JD, Sutter, TR, Hayes, JD, Harris, TM

Chem. Res. Toxicol. 2001
12727802 Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter

Slattery, CM, Hayes, JD, Ellis, EM

Carcinogenesis 2003
Participants
Participates
Catalyst Activity

aldo-keto reductase (NADP) activity of AKR dimers [cytosol]

Orthologous Events
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