AKR dimers reduce AFBDHO to AFBDOH

Stable Identifier
R-HSA-5423637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Aflatoxin B1 aldehyde reductases (AKR7A2, AKR7A3 and AKR7L) are dimeric, cytosolic, NADPH-dependent enzymes able to catalyse the reduction of aflatoxin B1 dialdehyde (AFBDHO) to aflatoxin B1-6,8-dialcohol (AFBDOH) (Ellis et al. 2003, Bodreddigari et al. 2008, Ireland et al. 1998, Guengerich et al. 2001). AKRs can turnover a vast range of substrates, including drugs, carcinogens, and reactive aldehydes. They play central roles in the metabolism of these agents, leading to either their bioactivation or detoxication (Jin & Penning 2007). The dialcohol is excreted in urine by conjugation with glucuronide (not shown here).

Literature References
PubMed ID Title Journal Year
18416522 Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3

Bodreddigari, S, Jones, LK, Egner, PA, Groopman, JD, Sutter, CH, Roebuck, BD, Guengerich, FP, Kensler, TW, Sutter, TR

Chem. Res. Toxicol. 2008
12727802 Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter

Ellis, EM, Slattery, CM, Hayes, JD

Carcinogenesis 2003
16970545 Aldo-keto reductases and bioactivation/detoxication

Jin, Y, Penning, TM

Annu. Rev. Pharmacol. Toxicol. 2007
9576847 Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase

Ireland, LS, Harrison, DJ, Neal, GE, Hayes, JD

Biochem. J. 1998
11409944 Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases

Guengerich, FP, Cai, H, McMahon, M, Hayes, JD, Sutter, TR, Groopman, JD, Deng, Z, Harris, TM

Chem. Res. Toxicol. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldo-keto reductase (NADP) activity of AKR dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created