CYP2A13 oxidises AFM1 to AFM1E

Stable Identifier
R-HSA-5423647
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytochrome P450 2A13 is able to oxidise aflatoxin M1 (AFM1) to the reactive aflatoxin M1 epoxide (AFM1E) (He et al. 2006). AFM1E is less carcinogenic or mutagenic than aflatoxin B1-exo-8,9-epoxide (AFBO), but is equally toxic. AFM1E would usually be detoxified by conjugation with glutathione, eventually excreted in urine as a mercapturic acid (not shown here).

Literature References
PubMed ID Title Journal Year
16385575 Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract

He, XY, Tang, L, Wang, SL, Cai, QS, Wang, JS, Hong, JY

Int. J. Cancer 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP2A13 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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