CYP1A2, 3A4 oxidise AFB1 to AFNBO

Stable Identifier
R-HSA-5423672
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aflatoxin B1 (AFB1) requires microsomal oxidation to produce epoxides which cause the toxic and carcinogenic effects. In humans, cytochrome P450 enzymes produce epoxide stereoisomers of AFB1, the most potent being aflatoxin exo-8,9-oxide (AFNBO). CYP3A4 and CYP1A2 can also produce aflatoxin B1-endo-8,9-epoxide (Raney et al. 1992, Ueng et al. 1995).

Literature References
PubMed ID Title Journal Year
1504254 The endo-8,9-epoxide of aflatoxin B1: a new metabolite

Guengerich, FP, Raney, KD, Coles, B, Harris, TM

Chem. Res. Toxicol. 1992
7766804 Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

Guengerich, FP, Yamazaki, H, Ueng, YF, Shimada, T

Chem. Res. Toxicol. 1995
Participants
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Catalyst Activity

monooxygenase activity of CYP1A2,3A4 [endoplasmic reticulum membrane]

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