CYP1A2 hydroxylates AFB1 to AFM1

Stable Identifier
R-HSA-5423678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aflatoxin B1 (AFB1) undergoes extensive oxidation, which is catalysed by cytochrome P450s. In addition to formation of the 8,9-oxide, oxidation by CYP1A2 yields a stable metabolite, aflatoxin M1 (AFM1), that is excreted in milk and urine (Ueng et al. 1995). AFM1 is less carcinogenic or mutagenic than AFB1, but is equally toxic.

Literature References
PubMed ID Title Journal Year
7766804 Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

Ueng, YF, Shimada, T, Yamazaki, H, Guengerich, FP

Chem. Res. Toxicol. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created