Reactome | PDCD4 [cytosol]

PDCD4 [cytosol]

Stable Identifier

R-HSA-5432887

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Programmed cell death protein 4, Nuclear antigen H731-like

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of Programmed cell death protein 4 (Homo sapiens)
        
        PDCD4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q53EL6 PDCD4

Gene Names

PDCD4, H731

Chain

chain:1-469

Reference Genes

BioGPS Gene:27250 PDCD4

COSMIC (genes):PDCD4 PDCD4

CTD Gene:27250 PDCD4

dbSNP Gene:27250 PDCD4

ENSEMBL:ENSG00000150593 PDCD4

HGNC:8763 PDCD4

Monarch:27250 PDCD4

NCBI Gene:27250 PDCD4

OMIM:608610 PDCD4

UCSC:Q53EL6 PDCD4

Reference Transcript

Other Identifiers

11741113_a_at

11741114_x_at

11743354_a_at

11743355_x_at

16709201

202730_PM_s_at

202730_s_at

202731_PM_at

202731_at

212593_3p_s_at

212593_PM_s_at

212593_s_at

212594_3p_at

212594_PM_at

212594_at

27250

3263945

3263947

3263948

3263950

3263954

3263956

3263957

3263958

3263960

3263961

3263962

3263963

3263965

3263966

3263967

3263968

3263970

3263971

3263972

3263974

3263977

3263978

3263979

3263980

3263982

39510_r_at

7930454

A_14_P105994

A_14_P106269

A_14_P124487

A_23_P258862

A_33_P3212092

GE56202

GE62663

GE88651

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0006915

GO:0009725

GO:0012501

GO:0030154

GO:0030509

GO:0034393

GO:0043066

GO:0043226

GO:0043279

GO:0043508

GO:0045892

GO:0050729

GO:0051246

GO:0060940

GO:0071222

GO:1900016

GO:1901224

GO:1904706

GO:1904761

GO:1905064

GO:1905461

GO:2000353

HMNXSV003030395

HMNXSV003042151

Hs.326248.1.A1_3p_at

Hs.326248.1.A2_3p_at

ILMN_1768004

ILMN_2396272

PH_hs_0023291

PH_hs_0032355

TC10000808.hg

U83908_at

g7657448_3p_at

g7657448_3p_s_at

Participates

as an output of

Expression of Programmed cell death protein 4 (Homo sapiens)

Cross References

ZINC - World Drugs

PDCD4_HUMAN

OpenTargets

ENSG00000150593

ENSEMBL

ENST00000393104, ENST00000280154, ENSP00000376816, ENSP00000280154

ZINC - FDA approved

PDCD4_HUMAN

ZINC - Substances

PDCD4_HUMAN

ZINC - Biogenic

PDCD4_HUMAN

ZINC target

Q53EL6

PRO

Q53EL6

GlyGen

Q53EL6

PDB

8XXL, 8XXN, 2ZU6, 8XXM, 3EIJ, 2GGF, 2KZT, 2RG8

HPA

ENSG00000150593-PDCD4

Pharos - Targets

Q53EL6

ZINC - Predictions - Purchasable

PDCD4_HUMAN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.93	11
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.718	6
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.675	6
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.599	6
UniProt:Q14240-2 EIF4A2			0.556	3
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.547	2
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	3
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.527	2
UniProt:Q9NW97 TMM51			0.527	2
UniProt:Q8IUE0 TF2LY			0.527	2
UniProt:P02649 APOE	10	APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [extracellular region] (R-HSA-174646) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.482	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.482	3