Reactome | DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG

DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG

Stable Identifier

R-HSA-5433067

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG

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In the formation of mercapturic acid from glutathione conjugates, first a glutamate residue is hydrolysed from the conjugate then a glycine residue (Gly). The dipeptidases 1,2 and 3 (DPEP1,2,3) perform this second hydrolysis. They are membrane-bound, homodimeric enzymes which require zinc ions for activity. DPEP1 has been characterised (Satoh et al. 1993, 1994, Nitanai et al. 2002) whereas DPEP2 and 3 are thought to function as DPEP1 based on similarity.

Literature References

PubMed ID	Title	Journal	Year
12144777	Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis Nitanai, Y, Satow, Y, Tsujimoto, M, Adachi, H	J. Mol. Biol.	2002
8439558	Cloning and structural analysis of genomic DNA for human renal dipeptidase Niwa, M, Konta, Y, Satoh, S, Kusunoki, C, Kohsaka, M	Biochim. Biophys. Acta	1993
7764673	Gene structural analysis and expression of human renal dipeptidase Niwa, M, Keida, Y, Konta, Y, Ohtsuka, K, Satoh, S, Kusunoki, C, Kohsaka, M	Biotechnol. Prog.	1994