GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG

Stable Identifier
R-HSA-5433072
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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To be excreted in urine, glutathione conjugates undergo several hydrolysis steps to form mercapturic acids which are readily excreted. The first step is the hydrolysis of a gamma-glutamyl residue from the conjugate catalysed by gamma-glutamyltransferases (GGTs). These are membrane-bound, heterodimeric enzymes composed of light and heavy peptide chains. GGT1 and 2 are well characterised while GGT3P, 5, 6 and 7 are putative transferases. Extracellular glutathione or its conjugates can be hydrolysed to give cysteinylglycine (CG, or CG conjugates) and free glutamate (L-Glu) (Heisterkamp et al. 2008, Tate & Ross 1977, Pawlak et al. 1989).

Literature References
PubMed ID Title Journal Year
2573352 Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney

Pawlak, A, Wu, SJ, Bulle, F, Suzuki, A, Chikhi, N, Ferry, N, Baik, JH, Siegrist, S, Guellaƫn, G

Biochem Biophys Res Commun 1989
18357469 The human gamma-glutamyltransferase gene family

Heisterkamp, N, Groffen, J, Warburton, D, Sneddon, TP

Hum Genet 2008
19463 Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit

Tate, SS, Ross, ME

J Biol Chem 1977
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione hydrolase activity of GGT dimers [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created