Reactome | ETF1 [cytosol]

ETF1 [cytosol]

Stable Identifier

R-HSA-54433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eukaryotic peptide chain release factor subunit 1, eRF1, Eukaryotic release factor 1, TB3-1, C11 protein

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Locations in the PathwayBrowser for interactor UniProt:Q14145 KEAP1

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External Reference Information

External Reference

UniProt:P62495 ETF1

Gene Names

ETF1, ERF1, RF1, SUP45L1

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:2107 ETF1

COSMIC (genes):ETF1 ETF1

CTD Gene:2107 ETF1

dbSNP Gene:2107 ETF1

ENSEMBL:ENSG00000120705 ETF1

ENSEMBL_homo_sapiens_GENE:ENSG00000120705.13 ETF1

HGNC:3477 ETF1

KEGG Gene (Homo sapiens):2107 ETF1

Monarch:2107 ETF1

NCBI Gene:2107 ETF1

OMIM:600285 ETF1

UCSC:P62495 ETF1

Reference Transcript

Other Identifiers

11721448_a_at

11721449_a_at

11721450_x_at

11721451_a_at

17000465

201573_PM_s_at

201573_s_at

201574_PM_at

201574_at

2107

2877466

2877467

2877468

2877469

2877470

2877471

2877472

2877473

2877474

2877476

2877477

2877479

2877480

2877481

2877494

2877495

2877496

2877497

2877498

2877500

2877502

2877504

37318_at

8114443

A_23_P133582

GE60073

GO:0000184

GO:0002181

GO:0002184

GO:0003723

GO:0003747

GO:0003824

GO:0004045

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006415

GO:0006449

GO:0006479

GO:0008079

GO:0016071

GO:0016149

GO:0016787

GO:0018444

GO:0022626

GO:0036211

GO:0043022

GO:0043226

GO:0045182

GO:0140098

GO:1990825

HMNXSV003024909

ILMN_2222992

M75715_s_at

PH_hs_0004457

TC05001831.hg

X81625_at

g338686_3p_a_at

g4759033_3p_at

Participates

as a component of

as an input of

Other forms of this molecule

Me-Q185-ETF1 [cytosol]

4OHK63-ETF1 [cytosol]

Inferred To

erf1 [cytosol] (Dictyostelium discoideum)

Etf1 [cytosol] (Mus musculus)

Etf1 [cytosol] (Rattus norvegicus)

sup45 [cytosol] (Schizosaccharomyces pombe)

erfa-1 [cytosol] (Caenorhabditis elegans)

ETF1 [cytosol] (Bos taurus)

ETF1 [cytosol] (Canis familiaris)

ETF1 [cytosol] (Gallus gallus)

ETF1 [cytosol] (Plasmodium falciparum)

ETF1 [cytosol] (Sus scrofa)

etf1 [cytosol] (Xenopus tropicalis)

SUP45 [cytosol] (Saccharomyces cerevisiae)

eRF1 [cytosol] (Drosophila melanogaster)

etf1b [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001278903.1, NP_001243231.1, XP_005271978.1, NP_001278904.1, NP_004721.1

OpenTargets

ENSG00000120705

HPA

ENSG00000120705-ETF1

GeneCards

P62495

Ensembl

ENST00000499810, ENSG00000120705, ENST00000360541, ENSP00000353741, ENSP00000421288

PRO

P62495

Pharos - Targets

P62495

PDB

6D90, 6IP8, 6XA1, 3J5Y, 5LZU, 4D5N, 3JAG, 4D61, 5A8L, 5LZV, 2LGT, 8SCB, 2HST, 3JAH, 3JAI, 2MQ6, 2KTU, 2LLX, 1DT9, 3E1Y, 6ZME, 2MQ9, 2KTV, 5LZT

HMDB Protein

HMDBP08381

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.831	8
UniProt:P15170 GSPT1	1	GSPT1 [cytosol] (R-HSA-8865759)	0.786	5
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.669	3
UniProt:Q96K76 USP47	1	USP47 [nucleoplasm] (R-HSA-5696961)	0.527	2
UniProt:Q9NVC3 S38A7			0.527	2
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.527	2
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2

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