Reactome | FADD [cytosol]

FADD [cytosol]

Stable Identifier

R-HSA-54639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity), FADD protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity

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Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88

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Literature References

PubMed ID	Title	Journal	Year
7538907	FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Dixit, VM, Tewari, M, O'Rourke, K, Chinnaiyan, AM	Cell	1995

External Reference Information

External Reference

UniProt:Q13158 FADD

Gene Names

FADD, MORT1, GIG3

Chain

chain:1-208

Reference Genes

BioGPS Gene:8772 FADD

COSMIC (genes):FADD FADD

CTD Gene:8772 FADD

dbSNP Gene:8772 FADD

ENSEMBL:ENSG00000168040 FADD

ENSEMBL_homo_sapiens_GENE:ENSG00000168040.5 FADD

HGNC:3573 FADD

KEGG Gene (Homo sapiens):8772 FADD

Monarch:8772 FADD

NCBI Gene:8772 FADD

OMIM:602457 FADD

UCSC:Q13158 FADD

Reference Transcript

RefSeq:NM_003824.3 FADD

Other Identifiers

11716799_at

11716800_at

16728331

202535_PM_at

202535_at

3338425

3338426

3338427

3338428

3338431

3338432

3338433

3338434

3338435

38755_at

7942168

8772

A_14_P110132

A_14_P123448

A_23_P86917

A_24_P278637

GE60092

GO:0001822

GO:0001916

GO:0002020

GO:0002376

GO:0002821

GO:0005123

GO:0005164

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006915

GO:0007155

GO:0007165

GO:0008625

GO:0009898

GO:0012501

GO:0023052

GO:0030154

GO:0031264

GO:0031265

GO:0032729

GO:0032757

GO:0032760

GO:0032813

GO:0032991

GO:0033077

GO:0033612

GO:0035591

GO:0035877

GO:0036462

GO:0042104

GO:0042220

GO:0042802

GO:0042981

GO:0043029

GO:0043065

GO:0043123

GO:0044297

GO:0044877

GO:0045087

GO:0045089

GO:0045651

GO:0045862

GO:0045944

GO:0048148

GO:0048535

GO:0048536

GO:0048538

GO:0048856

GO:0048870

GO:0051604

GO:0051607

GO:0060090

GO:0060340

GO:0060544

GO:0060546

GO:0065003

GO:0070236

GO:0071260

GO:0071550

GO:0089720

GO:0097049

GO:0097190

GO:0097191

GO:0097192

GO:0097202

GO:0097342

GO:0097527

GO:0098542

GO:1900119

GO:2000454

GO:2001238

HMNXSV003047418

ILMN_1758658

PH_hs_0004852

TC11000723.hg

X84709_at

g4505228_3p_at

Participates

as a component of

as an input of

Inferred To

FADD [cytosol] (Bos taurus)

FADD [cytosol] (Gallus gallus)

Fadd [cytosol] (Drosophila melanogaster)

Fadd [cytosol] (Mus musculus)

Fadd [cytosol] (Rattus norvegicus)

Ghost homologue of FADD [cytosol] (Canis familiaris)

Ghost homologue of FADD [cytosol] (Xenopus tropicalis)

TNFRSF6 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003815.1

OpenTargets

ENSG00000168040

HPA

ENSG00000168040-FADD

GeneCards

Q13158

Ensembl

ENSP00000301838, ENST00000301838, ENSG00000168040

PRO

Q13158

Pharos - Targets

Q13158

Orphanet

21426

PDB

2GF5, 3OQ9, 3EZQ, 1A1Z, 7LXC, 1A1W, 6ACI, 1E3Y, 1E41

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.98	47
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.96	23
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.928	12
UniProt:P50591 TNFSF10	1	TNFSF10 [extracellular region] (R-HSA-66186)	0.913	19
UniProt:Q13158 FADD	1	FADD [cytosol] (R-HSA-54639)	0.885	12
UniProt:P25445-1 FAS			0.883	17
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.806	7
UniProt:P25446	1	Fas [plasma membrane] (R-MMU-66248)	0.772	8
UniProt:Q92851 CASP10	4	CASP10(220-415) [cytosol] (R-HSA-933458) CASP10(1-219) [cytosol] (R-HSA-933454) CASP10(416-521) [cytosol] (R-HSA-933455) CASP10(1-521) [cytosol] (R-HSA-933453)	0.75	4
UniProt:P48023 FASLG	1	FASLG(1-281) [extracellular region] (R-HSA-66212)	0.731	4
UniProt:O00220 TNFRSF10A	1	TNFRSF10A [plasma membrane] (R-HSA-5633393)	0.725	6
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.676	9
UniProt:Q99497 PARK7	7	monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351) PARK7 [nucleoplasm] (R-HSA-3900141) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) Misfolded PARK7 [cytosol] (R-HSA-9641100) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997)	0.653	9
UniProt:P03126 VE6			0.593	4
UniProt:B7UI21 NLEB1			0.593	7
UniProt:O95243 MBD4	1	MBD4 [nucleoplasm] (R-HSA-3006633)	0.581	6
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.573	3
UniProt:Q14790-5 CASP8			0.567	4
UniProt:Q15560 TCEA2			0.556	3
UniProt:P62324 BTG1	1	BTG1 [nucleoplasm] (R-HSA-9620886)	0.556	5
UniProt:Q9UJ78-2 Q9UJ782			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q6PEW1 ZCH12			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	5
UniProt:B7ZLH0 B7ZLH0			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	6
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.527	2
UniProt:O43422 P52K			0.527	2
UniProt:O14763 TNFRSF10B	1	TNFRSF10B [plasma membrane] (R-HSA-65505)	0.527	4
IntAct:EBI-16074260 EHECNLEB1			0.508	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.499	4
UniProt:Q14790-1 CASP8			0.482	5

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