Genomic deletions of the entire AMER1/WTX gene occur in about 12% of Wilms tumors, a pediatric kidney cancer. Nonsense and missense mutations have also been identified (Ruteshouser et al, 2008; Wegert et al, 2009). AMER1 is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabilizes cellular beta-catenin levels and increases the expression of a beta-catenin-dependent reporter gene, suggesting that AMER1 is a tumor suppressor gene (Major et al, 2007; reviewed in Huff, 2011).
Huff, V
Wegert, J, Wittmann, S, Leuschner, I, Geissinger, E, Graf, N, Gessler, M
Major, MB, Camp, ND, Berndt, JD, Yi, X, Goldenberg, SJ, Hubbert, C, Biechele, TL, Gingras, AC, Zheng, N, Maccoss, MJ, Angers, S, Moon, RT
Ruteshouser, EC, Robinson, SM, Huff, V
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