Deletions in the AMER1 gene destabilize the destruction complex

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R-HSA-5467343
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Pathway
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Homo sapiens
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Genomic deletions of the entire AMER1/WTX gene occur in about 12% of Wilms tumors, a pediatric kidney cancer. Nonsense and missense mutations have also been identified (Ruteshouser et al, 2008; Wegert et al, 2009). AMER1 is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabilizes cellular beta-catenin levels and increases the expression of a beta-catenin-dependent reporter gene, suggesting that AMER1 is a tumor suppressor gene (Major et al, 2007; reviewed in Huff, 2011).

Literature References
PubMed ID Title Journal Year
21248786 Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

Huff, V

Nat. Rev. Cancer 2011
19760609 WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact

Wegert, J, Wittmann, S, Leuschner, I, Geissinger, E, Graf, N, Gessler, M

Genes Chromosomes Cancer 2009
17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

Major, MB, Camp, ND, Berndt, JD, Yi, X, Goldenberg, SJ, Hubbert, C, Biechele, TL, Gingras, AC, Zheng, N, Maccoss, MJ, Angers, S, Moon, RT

Science 2007
18311776 Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors

Ruteshouser, EC, Robinson, SM, Huff, V

Genes Chromosomes Cancer 2008
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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