Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling

Stable Identifier
R-HSA-5467345
Type
Pathway
Species
Homo sapiens
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Deletions in the AXIN1 gene have been identified in 2 hepatocellular carcinoma cell lines. These deletions, which remove the N-terminal exons of the gene, compromise AXIN1 expression and result in elevated expression of a TCF-dependent reporter (Satoh et al, 2000, reviewed in Salahshor and Woodgett, 2005).

Literature References
PubMed ID Title Journal Year
10700176 AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Satoh, S, Daigo, Y, Furukawa, Y, Kato, T, Miwa, N, Nishiwaki, T, Kawasoe, T, Ishiguro, H, Fujita, M, Tokino, T, Sasaki, Y, Imaoka, S, Murata, M, Shimano, T, Yamaoka, Y, Nakamura, Y

Nat. Genet. 2000
15735151 The links between axin and carcinogenesis

Salahshor, S, Woodgett, JR

J. Clin. Pathol. 2005
Participants
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Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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