Hh processing variants are ubiquitinated

Stable Identifier
R-HSA-5483238
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Processing-defective SHH variants are ubiquitinated by SYVN1 (Chen et al, 2011).

Literature References
PubMed ID Title Journal Year
21357747 Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

Chen, X, Tukachinsky, H, Huang, CH, Jao, C, Chu, YR, Tang, HY, Mueller, B, Schulman, S, Rapoport, TA, Salic, A

J. Cell Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of SHH processing variants:ERLEC:OS9:SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
holoprosencephaly 4621 Holoprosencephaly sequence (disorder)
Authored
Reviewed
Created