Reactome | HSD17B12 [endoplasmic reticulum membrane]

HSD17B12 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-548766

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Estradiol 17-beta-dehydrogenase 12

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q53GQ0 HSD17B12

Gene Names

HSD17B12, SDR12C1

Chain

chain:1-312

Reference Genes

BioGPS Gene:51144 HSD17B12

COSMIC (genes):HSD17B12 HSD17B12

CTD Gene:51144 HSD17B12

dbSNP Gene:51144 HSD17B12

ENSEMBL:ENSG00000149084 HSD17B12

HGNC:18646 HSD17B12

KEGG:hsa:51144 HSD17B12

Monarch:51144 HSD17B12

NCBI Gene:51144 HSD17B12

OMIM:609574 HSD17B12

UCSC:Q53GQ0 HSD17B12

Reference Transcript

RefSeq:NM_016142.2 HSD17B12

Other Identifiers

11731605_s_at

11750207_a_at

11759794_at

1554121_PM_at

1554121_at

1554122_PM_a_at

1554122_a_at

217869_PM_at

217869_at

3328100

3328101

3328102

3328103

3328126

3328129

3328130

3328141

3328143

3328145

3328147

3328156

3328157

3328161

3328162

3328163

3328167

3328168

3328169

3328170

3328171

3328172

49007_at

49468_at

51144

7939465

A_14_P106497

A_14_P123190

A_23_P371933

A_23_P47377

A_33_P3335042

GE62350

GE670552

GO:0001968

GO:0003824

GO:0004303

GO:0005515

GO:0005518

GO:0005783

GO:0005789

GO:0006629

GO:0006633

GO:0006694

GO:0006703

GO:0006790

GO:0008201

GO:0009923

GO:0010811

GO:0016020

GO:0016491

GO:0019367

GO:0030198

GO:0030312

GO:0031012

GO:0035338

GO:0043226

GO:0055086

GO:0141040

GO:1901135

HMNXSV003033442

Hs2.132513.1.S1_3p_s_at

ILMN_1702168

ILMN_2094106

PH_hs_0022489

TC11000367.hg

g7705854_3p_at

Participates

as a candidate of

HSD17B3-like Proteins [endoplasmic reticulum membrane] (Homo sapiens)

as a member of

HSD17B3,12 [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

spidey [endoplasmic reticulum membrane] (Drosophila melanogaster)

LOC789567 [endoplasmic reticulum membrane] (Bos taurus)

HSD17B12 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

HSD17B12 [endoplasmic reticulum membrane] (Canis familiaris)

HSD17B12 [endoplasmic reticulum membrane] (Danio rerio)

HSD17B12 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

HSD17B12 [endoplasmic reticulum membrane] (Gallus gallus)

HSD17B12 [endoplasmic reticulum membrane] (Mus musculus)

HSD17B12 [endoplasmic reticulum membrane] (Plasmodium falciparum)

HSD17B12 [endoplasmic reticulum membrane] (Rattus norvegicus)

HSD17B12 [endoplasmic reticulum membrane] (Sus scrofa)

HSD17B12 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000395700, ENSP00000379052, ENST00000278353, ENSP00000278353

OpenTargets

ENSG00000149084

IntEnz

1.1.1.62, 1.1.1.330

HPA

ENSG00000149084-HSD17B12

PRO

Q53GQ0

Pharos - Targets

Q53GQ0

GlyGen

Q53GQ0

HMDB Protein

HMDBP08861

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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