ACSL3,4 ligate CoA to AA to form AA-CoA

Stable Identifier
R-HSA-548843
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4]
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Acyl-CoA synthetase long-chain family member 4 (ACSL4) associated with the endoplasmic reticulum membrane catalyses the conjugation of arachidonate (AA) with CoA to form arachidonyl-CoA (AA-CoA) (Longo et al. 2003, Meloni et al. 2003). By similarity, ACSL3 can also preferentially conjugate CoA on to AA (Yao & Ye 2008). These enzymes are involved in the activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation.

Literature References
PubMed ID Title Journal Year
11889465 FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation

Meloni, I, Muscettola, M, Raynaud, M, Longo, I, Bruttini, M, Moizard, MP, Gomot, M, Chelly, J, des Portes, V, Fryns, JP, Ropers, HH, Magi, B, Bellan, C, Volpi, N, Yntema, HG, Lewis, SE, Schaffer, JE, Renieri, A

Nat Genet 2002
18003621 Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells

Yao, H, Ye, J

J. Biol. Chem. 2008
12525535 A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients

Longo, I, Frints, SG, Fryns, JP, Meloni, I, Pescucci, C, Ariani, F, Borghgraef, M, Raynaud, M, Marynen, P, Schwartz, C, Renieri, A, Froyen, G

J Med Genet 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
long-chain fatty acid-CoA ligase activity of ACSL3,4 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created