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NPRL3 [lysosomal membrane]
Stable Identifier
R-HSA-5490304
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Nitrogen permease regulator 3-like protein, NPRL3_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Amino acids regulate mTORC1 (Homo sapiens)
BMT2 (SAMTOR) binds S-adenosylmethionine and dissociates from KICSTOR:GATOR1 (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
CASTOR1 homodimer binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
CASTOR1 in CASTOR1:CASTOR2 binds L-arginine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
RRAGA,B hydrolyzes GTP (Homo sapiens)
KICSTOR:GATOR1:BMT2 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR1 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:CASTOR1:CASTOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
SESN1,2 binds L-leucine and dissociates from GATOR2 (Homo sapiens)
KICSTOR:GATOR1:GATOR2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1:GATOR2:SESN1,2 [lysosomal membrane] (Homo sapiens)
KICSTOR:GATOR1 [lysosomal membrane] (Homo sapiens)
GATOR1 [lysosomal membrane] (Homo sapiens)
NPRL3 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12980 NPRL3
Gene Names
NPRL3, C16orf35, CGTHBA, MARE
Chain
chain:1-569
Reference Genes
BioGPS Gene:8131 NPRL3
COSMIC (genes):NPRL3 NPRL3
CTD Gene:8131 NPRL3
dbSNP Gene:8131 NPRL3
ENSEMBL:ENSG00000103148 NPRL3
ENSEMBL_homo_sapiens_GENE:ENSG00000103148.17 NPRL3
HGNC:14124 NPRL3
KEGG Gene (Homo sapiens):8131 NPRL3
Monarch:8131 NPRL3
NCBI Gene:8131 NPRL3
OMIM:600928 NPRL3
UCSC:Q12980 NPRL3
Reference Transcript
RefSeq:NM_001077350.2 NPRL3
Other Identifiers
11724496_a_at
11724497_a_at
11748257_a_at
11753912_a_at
11763176_at
16822330
203289_PM_s_at
203289_s_at
210672_PM_s_at
210672_s_at
214273_PM_x_at
214273_x_at
3674893
3674894
3674895
3674896
3674897
3674902
3674903
3674905
3674906
3674910
3674913
3674917
3674918
3674921
3674922
3674924
3674928
3674936
3674939
3674940
3674941
3674943
40956_at
7998157
8131
A_23_P100326
A_24_P304969
GO:0003281
GO:0005096
GO:0005515
GO:0005764
GO:0005765
GO:0005773
GO:0006914
GO:0010508
GO:0016020
GO:0023052
GO:0032007
GO:0034198
GO:0035909
GO:0038202
GO:0043226
GO:0048738
GO:0048856
GO:0060021
GO:0098772
GO:1904262
GO:1990130
HMNXSV003021880
Hs.19699.0.A1_3p_a_at
Hs.19699.4.A1_3p_a_at
ILMN_1733581
ILMN_2273447
ILMN_2369580
PH_hs_0001725
TC16000722.hg
X90857_at
g13278839_3p_a_at
Participates
as a component of
GATOR1 [lysosomal membrane] (Homo sapiens)
Inferred To
nprl3 [lysosomal membrane]
(Xenopus tropicalis)
Nprl3 [lysosomal membrane]
(Mus musculus)
Nprl3 [lysosomal membrane]
(Rattus norvegicus)
NPRL3 [lysosomal membrane]
(Bos taurus)
NPRL3 [lysosomal membrane]
(Canis familiaris)
NPRL3 [lysosomal membrane]
(Dictyostelium discoideum)
NPRL3 [lysosomal membrane]
(Gallus gallus)
NPRL3 [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001070818.1
OpenTargets
ENSG00000103148
HPA
ENSG00000103148-NPRL3
GeneCards
Q12980
Ensembl
ENST00000611875
,
ENSP00000478273
,
ENSG00000103148
PRO
Q12980
Pharos - Targets
Q12980
HMDB Protein
HMDBP11866
PDB
7T3C
,
7T3A
,
6CET
,
8FW5
,
7T3B
,
6CES
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