OCT1 transports organic cations into hepatic cells

Stable Identifier
R-HSA-549129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The human gene SLC22A1 expresses the organic cation transporter 1 (OCT1) mainly in the liver. It can mediate the reversible transport of a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN) and 4-(4-(dimethylamino)styryl)-N-methylpyridinium (Zhang L et al, 1998; Gorboulev V et al, 1997).
Literature References
PubMed ID Title Journal Year
9260930 Cloning and characterization of two human polyspecific organic cation transporters

Koepsell, H, Ulzheimer, JC, Quester, S, Busch, AE, Akhoundova, A, Lang, F, Baumann, C, Karbach, U, Gorboulev, V, Ulzheimer-Teuber, I

DNA Cell Biol 1997
9655880 Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)

Zhang, L, Schaner, ME, Giacomini, KM

J Pharmacol Exp Ther 1998
Participants
Participates
Catalyst Activity

organic cation transmembrane transporter activity of OCT1 [plasma membrane]

Orthologous Events
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