1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]

Stable Identifier
R-HSA-549192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conversion of Diacylglycerol to Triacylglycerol [DGAT2]
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Diacylglycerol O-acyltransferase 1 (DGAT2) associated with the endoplasmic reticulum membrane catalyzes the reaction of 1,2-diacyl-glycerol and acyl-CoA to form triacylglycerol + CoASH (Cases et al. 2001, Wakimoto et al. 2003).

Literature References
PubMed ID Title Journal Year
14521909 A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice

Wakimoto, K, Chiba, H, Michibata, H, Seishima, M, Kawasaki, S, Okubo, K, Mitsui, H, Torii, H, Imai, Y

Biochem Biophys Res Commun 2003
11481335 Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

Cases, S, Stone, SJ, Zhou, P, Yen, E, Tow, B, Lardizabal, KD, Voelker, T, Farese, RV

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
diacylglycerol O-acyltransferase activity of DGAT2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Created